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cytotoxin P4
from Naja nigricollis nigricollis venom; shows preferential activity on tumour cells
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Complex Mixtures: 1906
Venoms: 4328
Snake Venoms: 1139
Elapid Venoms: 169
cytotoxin P4: 4
Biological Factors: 2472
Biological Toxins: 20
Venoms: 4328
Snake Venoms: 1139
Elapid Venoms: 169
cytotoxin P4: 4
Related Diseases
1.
Melanoma (Melanoma, Malignant)
09/01/1992 - "
The present study examined the binding of cytotoxin P4 to melanoma B16F10 and WEHI-3B leukemia cell lines and found that, like cytotoxicity, it depended on concentration, temperature and incubation time.
"
09/01/1992 - "
Binding of cytotoxin P4 from Naja nigricollis nigricollis to B16F10 melanoma and WEHI-3B leukemia cells.
"
01/01/1993 - "
Cytotoxin P4 isolated from the venom of the cobra Naja nigricollis nigricollis was encapsulated in liposomes by the reverse-phase evaporation method using phosphatidylcholine, cholesterol and phosphatidylethanolamine at molar ratios of 3:1:1. Cytotoxicity examination on murine melanoma B16F10 revealed that the activity of the entrapped cytotoxin did not change significantly and remained stable for at least 1 year at 4 degrees C without any significant leak from the liposomes (< 1%).
"
2.
Leukemia
09/01/1992 - "
The present study examined the binding of cytotoxin P4 to melanoma B16F10 and WEHI-3B leukemia cell lines and found that, like cytotoxicity, it depended on concentration, temperature and incubation time.
"
09/01/1992 - "
Binding of cytotoxin P4 from Naja nigricollis nigricollis to B16F10 melanoma and WEHI-3B leukemia cells.
"
09/01/1992 - "
The histopathological changes in WEHI-3B leukemia cells were followed by light and electronmicroscopy at different time intervals following exposure to cytotoxin P4 from Naja nigricollis nigricollis venom.
"
09/01/1992 - "
Histopathological changes in WEHI-3B leukemia cells following intoxication by cytotoxin P4 from Naja nigricollis nigricollis venom.
"
3.
Neoplasms (Cancer)
06/01/1991 - "
Isolation and characterization of a cytotoxin P4 from the venom of Naja nigricollis nigricollis preferentially active on tumor cells.
"
Related Drugs and Biologics
1.
Venoms
2.
Phosphatidylcholines (Phosphatidylcholine)
3.
Liposomes (Liposome)
4.
Cytotoxins (Cytolysins)
5.
Cholesterol
6.
phosphatidylethanolamine