bis(2,2'- bipyridyl)(dipyrido(3,2- alpha- 2',3'- c)phenazine)ruthenium (II)

serves as "molecular light switch" for DNA, displaying no photoluminescence in aqueous solution but luminescing intensively in presence of DNA; structure given in first source

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gasser, Gilles: 1 article (11/2017)
2.	Heinemann, Franz: 1 article (11/2017)
3.	Karges, Johannes: 1 article (11/2017)
4.	Qu, Bin: 1 article (01/2011)
5.	Zhang, Xiaoru: 1 article (01/2011)
6.	Zhao, Yanqing: 1 article (01/2011)
7.	Zhou, Huanran: 1 article (01/2011)

Related Diseases

1.	Neoplasms (Cancer) 11/21/2017 - "The most effective complex in this series, [Ru(bpy)2(dppz-7-OMe)]2+, showed IC50 values in the low micromolar range against several types of cancer cells upon light irradiation and, importantly, a high phototoxic index (PI) of >150. " 12/01/2023 - "All Ru(II) complexes displayed "light switch" properties, especially [Ru(bpy)2(diamino)]2+, [Ru(bpy)2(dppz)]2+, and [Ru(bpy)2(aap)]2+. Current work sheds light on how Ru(II) polypyridyl complexes interact with human telomeric DNA with possible application in cancer therapy or G-quadruplex sensing."
2.	Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction) 01/15/2011 - "CIPO (bis(2,4,5-trichlro-6-n-pentoxycarbonylphenyl)oxalate)-H(2)O(2)-9,10-diphenylanthrancene was selected as a CL system, which can produce appropriate exciting light and excite photoelectro active materials Ru(bpy)(2)dppz(2+) intercalated into the double-stranded DNA. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	bis(bipyridyl)ruthenium(II)
3.	antiarrhythmic peptide (AAP)

Related Therapies and Procedures

1.	Therapeutics