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kynostatin 272

structure given in first source; contains allophenylnorstatine as a transition-state mimic

Also Known As:

KNI 272; KNI-272; kynostatin; kynostatin-272

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - kynostatin 272: 7

Experts

1.	Churchill, D R: 1 article (03/2001)
2.	Gazzard, B G: 1 article (03/2001)
3.	Slade, P M: 1 article (03/2001)
4.	Weber, J N: 1 article (03/2001)
5.	Youle, M: 1 article (03/2001)

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 11/01/1993 - "Although the anti-AIDS virus activity of these two drugs has not been investigated in vivo, KNI-272 is expected to be a better candidate for oral anti-AIDS therapies." 08/01/1994 - "Kynostatin (KNI-272), an experimental HIV protease inhibitor, is currently undergoing preclinical testing for the treatment of AIDS. " 02/01/1999 - "A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection."
2.	HIV Infections (HIV Infection) 07/01/1998 - "We studied the pharmacokinetics of KNI-272 in the plasma and cerebrospinal fluid (CSF) of a nonhuman primate model and after intravenous and oral administration to children with HIV infection. " 02/01/1999 - "A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection."
3.	Infections 03/01/2001 - "A phase I/II study of the safety and activity of a microsphere formulation of KNI-272 in patients with HIV-1 infection."
4.	Coinfection 12/01/1997 - "Co-infection of MT-2 cells with HIV-1SUM13 carrying the RT mutations and HIV-1SUM431 carrying the mutations in the protease also generated HIV-1 with both sets of mutations when cultured with AZT and KNI-272. "
5.	Neuroblastoma 11/01/1999 - "Kynostatin and 17beta-estradiol prevent the apoptotic death of human neuroblastoma cells exposed to HIV-1 protease."

Related Drugs and Biologics

1.	Human immunodeficiency virus 1 p16 protease
2.	HIV Protease Inhibitors
3.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Therapeutics
3.	Oral Administration