4'- demethylamino- 4'- hydroxy- 3'- epistaurosporine

structure given in first source; isolated from Streptomyces

Also Known As:

RK 1409B; RK-1409B; 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-11-hydroxy-10-methoxy-9-methyl-, (9R-(9alpha,10alpha,11beta,13alpha))-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        4'-demethylamino-4'-hydroxy-3'-epistaurosporine: 1
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - 4'-demethylamino-4'-hydroxy-3'-epistaurosporine: 1

Related Diseases

1.	Leukemia 09/01/1992 - "RK-1409B inhibited protein kinase C in vitro and the morphological change of a human chronic leukemia cell line, K-562, induced by phorbol 12,13-dibutyrate with IC50 value of 0.4 microM."

Related Drugs and Biologics

1.	Phorbol 12,13-Dibutyrate
2.	Protein Kinase C