dynorphin A-converting enzyme

highly specific enzyme from human spinal cord which converts dynorphin A(1-17) to Leu-enkephalin and its COOH-terminal extensions Leu-enkephalin-Arg6 and Leu-enkephalin-Arg6-Arg7

Also Known As:

DCE-A

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Cysteine Proteases: 1964
        Cysteine Endopeptidases: 4
        dynorphin A-converting enzyme: 9
      - Endopeptidases: 633
        Cysteine Endopeptidases: 4
        dynorphin A-converting enzyme: 9

Experts

1.	English, James: 1 article (01/2022)
2.	Essers, Brigitte: 1 article (01/2022)
3.	Maas, Jacques W M: 1 article (01/2022)
4.	Metzemaekers, Jeroen: 1 article (01/2022)
5.	Sampat, Jonathan: 1 article (01/2022)
6.	Smeets, Mathilde J G H: 1 article (01/2022)
7.	Thijs, Elke: 1 article (01/2022)
8.	Willem Jansen, Frank: 1 article (01/2022)
9.	van den Akker-van Marle, M Elske: 1 article (01/2022)
10.	Arrigoni, Francesco: 1 article (12/2020)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2020 - "This feature would give the DCE a secondary role, probably limited to a second evaluation of the lesion location, for detecting small cancer or in case of controversy. " 07/01/1998 - "This study investigates the potential of urethane-induced lung tumors to activate 1,1-dichloroethylene (DCE), a chemical that causes Clara cell damage in mice. "
2.	Lung Injury 05/05/2014 - "The aim of this study was to investigate the effect of costunolide (CS) and dehydrocostuslactone (DCE) a well-known sesquiterpene lactones contained in many plants, in a model of lung injury induced by carrageenan administration in the mice. "
3.	Carcinogenesis 01/01/1999 - "To test this hypothesis, we investigated 1,1-dichloroethylene (DCE), a chemical that causes Clara cell damage, in a urethane-induced model of lung tumorigenesis. "
4.	Takotsubo Cardiomyopathy 09/01/2009 - "In the 9 (11%) who exhibited abnormal contractility on baseline echocardiography with subsequent normalization, CMR did not show DCE, a finding that is characteristic of Takotsubo cardiomyopathy. "
5.	Low Back Pain (Lumbago) 11/01/1990 - "The activity levels of a dynorphin converting enzyme (DCE), a substance P endopeptidase (SPE) and a substance P alpha-amidating enzyme (SP-GLYE) were measured in the cerebrospinal fluid (CSF) of 90 patients with chronic low back pain, sciatica and neurological signs of rhizopathy. "

Related Drugs and Biologics

1.	Urethane (Ethyl Carbamate)
2.	vinylidene chloride (1,1-dichloroethylene)
3.	Sesquiterpenes
4.	Lactones
5.	Carrageenan
6.	dehydrocostus lactone
7.	costunolide
8.	Substance P
9.	Enzymes
10.	dynorphin converting enzyme

Related Therapies and Procedures

1.	Conservative Treatment