HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
4- methyl- 3- methylsulfonyl- 5- phenyl- 4H- 1,2,4- triazole
structure given in first source; selectively reverses strychnine-induced seizures
Also Known As:
5-phenyl-4-methyl-3-(methylsulfonyl)-4H-1,2,4-triazole; MDL 27,531; MDL 27531; MDL-27531; 4H-1,2,4-Triazole, 4-methyl-3-(methylsulfonyl)-5-phenyl-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Triazoles: 1533
4-methyl-3-methylsulfonyl-5-phenyl-4H-1,2,4-triazole: 2
Related Diseases
1.
Seizures (Absence Seizure)
08/01/1992 - "
MDL 27,531 blocked pentylenetetrazol-induced seizures with an ED50 = 55 mg kg-1.
"
08/01/1992 - "
2. MDL 27,531 (4-methyl-3-methylsulphonyl-5-phenyl-4H-1,2,4-triazole) blocked strychnine-induced tonic extensor seizures in mice following either intraperitoneal (ED50 = 12.8 mg kg-1; 30 min) or oral (ED50 = 7.3 mg kg-1; 30 min) administration.
"
08/01/1992 - "
MDL 27,531 selectively reverses strychnine-induced seizures in mice.
"
11/23/1992 - "
MDL 27,531, which acts functionally like a glycine agonist in its capacity to selectively reverse seizures produced by the glycine antagonist strychnine, was evaluated in a model of spinal injury-induced reflex dysfunction.
"
08/01/1992 - "
4. The antagonism of strychnine seizures by MDL 27,531 occurred at doses that did not produce signs of sedation (suppression of spontaneous motor activity), motor ataxia (disruption of rotarod performance), muscle relaxation (inhibition of morphine-induced Straub tail), or CNS depression (potentiation of hexobarbitone sleep time).
"
2.
Ataxia (Dyssynergia)
11/23/1992 - "
In its therapeutic dose range, clonidine, but not MDL 27,531, produced ataxia in non-transected rats.
"
08/01/1992 - "
4. The antagonism of strychnine seizures by MDL 27,531 occurred at doses that did not produce signs of sedation (suppression of spontaneous motor activity), motor ataxia (disruption of rotarod performance), muscle relaxation (inhibition of morphine-induced Straub tail), or CNS depression (potentiation of hexobarbitone sleep time).
"
3.
Spinal Injuries (Spinal Injury)
11/23/1992 - "
MDL 27,531, which acts functionally like a glycine agonist in its capacity to selectively reverse seizures produced by the glycine antagonist strychnine, was evaluated in a model of spinal injury-induced reflex dysfunction.
"
4.
Muscle Spasticity (Spastic)
11/23/1992 - "
These data suggest that MDL 27,531 may be a useful therapeutic agent for the treatment of dysfunctions of reflex control seen in spastic disorders of spinal origin, with potentially fewer side effects than are seen with existing drug therapies.
"
Related Drugs and Biologics
1.
Strychnine
2.
Glycine Receptors (Glycine Receptor)
3.
Quinolinic Acid
4.
Picrotoxin
5.
Pentylenetetrazole (Metrazol)
6.
Morphine (MS Contin)
7.
Ligands
8.
Hexobarbital (Hexenal)
9.
Glycine (Aminoacetic Acid)
10.
gamma-Aminobutyric Acid (GABA)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)