vulpinic acid

RN given refers to cpd without isomeric designation; structure given in first source; vulpinic acid refers to (E)-isomer

Also Known As:

methyl (2E)-(5-hydroxy-3-oxo-4-phenyl-2(3H)-furanylidene)(phenyl)acetate; vulpinic acid, (E)-isomer; vulpinic acid, potassium salt, (E)-isomer; Benzeneacetic acid, alpha-(3-hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)-, methyl ester, (alphaE)-

Networked: 10 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cansaran-Duman, Demet: 3 articles (11/2021 - 01/2018)
2.	Badreldin, Amr: 1 article (01/2022)
3.	Bagheri, Leila: 1 article (01/2022)
4.	Fatehi, Pedram: 1 article (01/2022)
5.	Mohammadi, Mahshid: 1 article (01/2022)
6.	Pakzad, Leila: 1 article (01/2022)
7.	Suntres, Zacharias: 1 article (01/2022)
8.	van Wijnen, Andre J: 1 article (01/2022)
9.	Du, Shijian: 1 article (01/2022)
10.	Gan, Dongmei: 1 article (01/2022)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "In this study, the effects of Vulpinic Acid (VA) lichen secondary metabolite on the cell viability and apoptosis of breast cancer cells and non-cancerous cell line were investigated. " 12/01/2022 - "The findings reveal that vulpinic acid may be a novel inhibitor candidate on TrxR1 and could be considered a potential chemotherapeutic agent for breast cancer treatment, especially in MCF-7 cells." 11/07/2021 - "The antiproliferative effect of vulpinic acid was screened against MCF-7 breast cancer cells and MCF-12A breast epithelial cells using the xCELLigence real-time cell analysis system. " 11/07/2021 - "This study revealed the molecular mechanisms of vulpinic acid on breast cancer and showed that vulpinic acid regulates apoptosis signaling pathways by decreasing the expression of miRNAs. " 11/07/2021 - "This is the first study to reveal that vulpinic acid inhibits the expression of 12 miRNAs and suppresses breast cancer cell proliferation. "
2.	Carcinoma (Carcinomatosis) 01/01/2022 - "Anti-ageing and Anti-lung Carcinoma Effects of Vulpinic Acid and Usnic Acid Compounds and Biological Investigations with Molecular Modeling Study."
3.	Neoplasms (Cancer) 08/01/2021 - "Vulpinic acid (VA) obtained from Letharia vulpina lichen species exerts a remarkable cytotoxic effect on different cancer types. " 01/01/2015 - "Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line. " 11/07/2021 - "Vulpinic acid, methyl (as2E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-2 phenylacetate, is a natural product extracted from the lichen species and shows an anticancer effect on different cancer cells. " 12/23/2019 - "Vulpinic acid, a naturally occurring methyl ester of pulvinic acid, has been reported to exert anti-fungal, anti-cancer, and anti-oxidative effects. " 01/05/2022 - "This review focuses on the lichen-derived metabolite gyrophoric acid and other select secondary metabolites (e.g., usnic acid, salazinic acid, physodic acid, vulpinic acid ceratinalone, flavicansone, ramalin, physciosporin, tumidulin, atranorin, parmosidone) that modulate a number of cellular pathways relevant to several biomedical diseases and disorders, including cancer, diabetes and cardiovascular disease. "
4.	Atherosclerosis 06/01/2019 - "Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis."
5.	Prostatic Neoplasms (Prostate Cancer) 08/01/2021 - "Vulpinic acid as a natural compound inhibits the proliferation of metastatic prostate cancer cells by inducing apoptosis."

Related Drugs and Biologics

1.	usnic acid
2.	MicroRNAs (MicroRNA)
3.	Thioredoxin Reductase 1
4.	Messenger RNA (mRNA)
5.	Esters
6.	Doxorubicin (Adriamycin)
7.	Ramalin
8.	pulvinic acid
9.	gyrophoric acid
10.	salazinic acid

Related Therapies and Procedures

1.	Therapeutics