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4,8- dihydro- 4- hydroxy- 8- oxo- 2'- deoxyguanosine

structure given in first source; RN given refers to the (4S)-isomer

Also Known As:

4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine, (4S)-isomer; 4-OH-8-O-2'dG

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Guanosine: 1156
        Deoxyguanosine: 166
        4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Guanosine: 1156
      - Deoxyguanosine: 166
        4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine: 2
  - Deoxyribonucleosides: 34
    - Deoxyguanosine: 166
      - 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine: 2

Related Diseases

1.

Photosensitivity Disorders (Photodermatitis)

07/25/1995 - "The primary products of the methylene blue-mediated photosensitization of 8-oxodG are 2-amino-5-((2-deoxy-beta-D-erythro-pentofuranosyl)amino)-4H-imidazol-4-o ne (dIz), 2,2-diamino-4-((2-deoxy-beta-D-erythro-pentofuranosyl)amino)-5(2H)-oxazo lone (dZ), the 4R* and 4S* diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine (dO), and an as yet unidentified product with a molecular weight of 287 (dX). "
09/25/1992 - "Phthalocyanine mediated photosensitization of 2'-deoxyguanosine (dG) in oxygen saturated aqueous solution has previously been shown to result in the addition of molecular oxygen to the guanine base generating the 4R* and 4S* diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine (dO) (the asterisk denotes unambiguous assignment of the 4R and 4S diastereoisomers). "

Related Drugs and Biologics

1.	Solutions
2.	Oxygen (Dioxygen)
3.	Methylene Blue (Methylthioninium Chloride)
4.	Guanine
5.	8-Hydroxy-2'-Deoxyguanosine
6.	phthalocyanine