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cyclo-RGDPhg
highly specific antagonist for gpIIb/IIIa on platelets; used to study RGD peptide mediated inhibition of tumor metastasis
Also Known As:
cyclic arginyl-glycyl-aspartyl-phenylglycyl; cyclo-Arg-Gly-Asp-PhGly
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
cyclo-RGDPhg: 1
Oligopeptides: 519
cyclo-RGDPhg: 1
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
cyclo-RGDPhg: 1
Related Diseases
1.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/31/1992 - "
A novel cyclic tetrapeptide containing L-arginine-glycine-L-aspartic acid-L-phenylglycine (cyclo-RGDPhg) was synthesized and found to be a potent inhibitor of platelet aggregation induced by highly metastatic murine squamous cell carcinoma (SCCVII) cells (IC50 = 3.3 microM) as well as ADP (1.5 microM).
"
Related Drugs and Biologics
1.
Glycine (Aminoacetic Acid)
2.
Aspartic Acid (Aspartate)
3.
Arginine (L-Arginine)
4.
Adenosine Diphosphate (ADP)
5.
2-phenylglycine