|1.||Ghribi, Othman: 10 articles (12/2015 - 12/2008)|
|2.||Lütjohann, Dieter: 6 articles (02/2015 - 01/2004)|
|3.||Marwarha, Gurdeep: 5 articles (08/2015 - 01/2010)|
|4.||Nelson, Erik R: 5 articles (12/2014 - 08/2010)|
|5.||McDonnell, Donald P: 5 articles (12/2014 - 08/2010)|
|6.||Umetani, Michihisa: 5 articles (07/2014 - 10/2007)|
|7.||Björkhem, Ingemar: 4 articles (01/2011 - 01/2004)|
|8.||Javitt, Norman B: 4 articles (08/2010 - 05/2002)|
|9.||Leonarduzzi, Gabriella: 3 articles (08/2015 - 06/2011)|
|10.||Poli, Giuseppe: 3 articles (08/2015 - 06/2011)|
01/01/2013 - "In the present study, we show that the cholesterol oxidation product 27-hydroxycholesterol (27-OHC) increases BACE1 and Aβ levels in human neuroblastoma SH-SY5Y cells. "
02/01/2012 - "Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol."
01/01/2010 - "We have recently shown that the cholesterol oxidation metabolite 27-hydroxycholesterol (27-OHC) causes AD-like pathology in human neuroblastoma SH-SY5Y cells and in organotypic hippocampal slices. "
01/01/2009 - "Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells."
12/01/2008 - "Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells."
|2.||Breast Neoplasms (Breast Cancer)
09/01/2015 - "Both receptors seem to mediate adverse effects of 27-hydroxycholesterol in breast cancer when the levels of this oxysterol are elevated. "
11/14/2013 - "27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth."
11/29/2013 - "27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology."
12/01/2014 - "In addition, studies demonstrate that the metabolite, 27-hydroxycholesterol (27HC), can function as an estrogen, increasing the proliferation of estrogen receptor (ER)-positive breast cancer cells. "
12/01/2015 - "The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells."
|3.||Atherosclerotic Plaque (Atheroma)
05/01/2002 - "Accumulation of 27-hydroxycholesterol in human atheroma is puzzling and may reflect low levels of oxysterol 7alpha-hydroxylase activity in human macrophages. "
02/18/1997 - "The concentration of 27-hydroxycholesterol in the atherosclerotic rabbit vessels was also lower compared to human atherosclerotic plaques. "
08/01/2015 - "Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability."
02/01/2015 - "24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54-84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45-78 years, controls). "
09/15/2006 - "In the present study, we investigated the cytotoxic effects of 7beta-hydroxycholesterol (7betaOH), 7-ketocholesterol (7keto), 25-hydroxycholesterol (25OH), and 27-hydroxycholesterol (27OH) on U937 monocytic cells, both individually and in atheroma-relevant mixtures mimicking the oxysterol composition reported in human atheroma lesions. "
01/01/2005 - "Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid."
01/01/2005 - "Concordant with previous studies, a strong correlation was observed between circulating levels of 27-hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. "
07/01/2014 - "The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha."
12/01/1994 - "Because of this relationship and also in view of the accelerated atherosclerosis and cholesterol deposition in tissues that occur as a consequence of genetically determined sterol 27-hydroxylase deficiency and of the potent biologic effect of 27-hydroxycholesterol in cell culture, it is proposed that this metabolic pathway serves a regulatory function. "
08/01/2015 - "This study aimed to determine the effects on TLR4 activation of two reactive oxidized lipids carried by oxidized low-density lipoproteins, the oxysterol 27-hydroxycholesterol (27-OH) and the aldehyde 4-hydroxynonenal (HNE), both of which accumulate in atherosclerotic plaques and play a key role in the pathogenesis of atherosclerosis. "
|5.||Alzheimer Disease (Alzheimer's Disease)
01/01/2011 - "Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus."
01/01/2011 - "Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease."
08/01/2015 - "Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?"
01/01/2006 - "The levels of 27-hydroxycholesterol in the circulation are correlated with the levels of cholesterol and the possibility must be considered that the flux of 27-hydroxycholesterol into the brain is the missing link between hypercholesterolemia and Alzheimer's disease. "
08/01/2010 - "Cerebral and extracerebral cholesterol metabolism are altered in Alzheimer's disease (AD) as indicated by reduced plasma levels of the cholesterol elimination products 24S-hydroxycholesterol, which is of cerebral origin, and of 27-hydroxycholesterol, which is formed extracerebrally. "
|4.||cholest-5-en-3 beta,7 alpha-diol
|6.||Biological Markers (Surrogate Marker)
|8.||Cyclooxygenase 2 (Cyclooxygenase-2)
|9.||Toll-Like Receptor 4
|10.||LDL Lipoproteins (beta Lipoproteins)