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MDS 004

structure given in first source; a pentaacetylated skikonin derivative

Also Known As:

MDS-004

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        MDS 004: 3
- Quinones: 434
  - Naphthoquinones: 418
    - MDS 004: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - MDS 004: 3

Experts

1.	Fenaux, Pierre: 2 articles (11/2014 - 03/2013)
2.	Muus, Petra: 2 articles (11/2014 - 03/2013)
3.	Benettaib, Bouchra: 1 article (11/2014)
4.	Beyne-Rauzy, Odile: 1 article (11/2014)
5.	Bowen, David: 1 article (11/2014)
6.	Fu, Tommy: 1 article (11/2014)
7.	Ganser, Arnold: 1 article (11/2014)
8.	Giagounidis, Aristoteles: 1 article (11/2014)
9.	Guerci-Bresler, Agnès: 1 article (11/2014)
10.	Göhring, Gudrun: 1 article (11/2014)

Related Diseases

1.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 11/01/2014 - "A subset analysis of the randomised, phase 3, MDS-004 study to evaluate outcomes in patients with International Prognostic Scoring System (IPSS)-defined Low-/Intermediate (Int)-1-risk myelodysplastic syndromes (MDS) with isolated del(5q). " 11/01/2014 - "Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study."
2.	Wounds and Injuries (Trauma) 04/01/1992 - "However, MDS-004, as well as commercial wound healing drugs tested and shikonin, did not show any healing action in the incised and open wound models in rats, if applied topically to the wound as 5 and 10% powders. "
3.	Stomach Ulcer (Gastric Ulcer) 04/01/1992 - "Orally administered MDS-004, unlike shikonin, inhibited carrageenan-induced hind paw edema, and exhibited tendency to heal acetic acid-induced gastric ulcer in rats. "
4.	Neoplasms (Cancer) 03/01/2013 - "We report health-related quality of life (HRQL) outcomes assessed using the Functional Assessment of Cancer Therapy-Anemia (FACT-An) among 167 RBC transfusion-dependent patients with IPSS Low-/Intermediate-1-risk del5q31 MDS treated with lenalidomide versus placebo in a randomized phase 3 clinical trial, MDS-004. "
5.	Hypersensitivity (Allergy) 04/01/1992 - "These results suggest that a white powder MDS-004, different from deep purple shikonin, has accelerating action on granuloma formation without irritative action and stronger inhibitory action on delayed-type allergy by topical application than shikonin."

Related Drugs and Biologics

1.	Lenalidomide (CC 5013)
2.	Acetic Acid (Vinegar)
3.	Powders
4.	Carrageenan
5.	shikonin

Related Therapies and Procedures

1.	Therapeutics