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methysticin

a neuroprotective constituent of kava extract; RN given for (R-(E))-isomer

Also Known As:

methysticin, ((E)-(+-))-isomer

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - methysticin: 4

Experts

1.	Brandenburg, Lars-Ove: 1 article (01/2017)
2.	Fendt, Markus: 1 article (01/2017)
3.	Fragoulis, Athanassios: 1 article (01/2017)
4.	Jansen, Sandra: 1 article (01/2017)
5.	Pufe, Thomas: 1 article (01/2017)
6.	Siegl, Stephanie: 1 article (01/2017)
7.	Soppa, Ulf: 1 article (01/2017)
8.	Weis, Joachim: 1 article (01/2017)
9.	Wruck, Christoph Jan: 1 article (01/2017)
10.	Cheng, Xun: 1 article (11/2005)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - "Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease." 11/01/2005 - "Based on previous reports of compounds that either bind to Abeta or are useful in treating Alzheimer's disease, melatonin, methysticin, 3-indolepropionic acid, and daunomycin were assayed and ranked in order of inhibition of Abeta aggregation. "
2.	Memory Disorders (Memory Loss) 01/01/2017 - "In summary, these findings show that methysticin administration activates the Nrf2 pathway and reduces neuroinflammation, hippocampal oxidative damage and memory loss in a mouse model of AD. "
3.	Ischemia 05/14/1992 - "Methysticin, dihydromethysticin (both 10 and 30 mg/kg, 15 min before ischemia) and memantine (20 mg/kg, 30 min before ischemia) significantly reduced the infarct area in mouse brains. "
4.	Infarction (Infarctions) 05/14/1992 - "Methysticin, dihydromethysticin (both 10 and 30 mg/kg, 15 min before ischemia) and memantine (20 mg/kg, 30 min before ischemia) significantly reduced the infarct area in mouse brains. "
5.	Gliosis 01/01/2017 - "However, methysticin treatment significantly reduced microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. "

Related Drugs and Biologics

1.	Interleukin-17 (Interleukin 17)
2.	Cytokines
3.	Memantine (Namenda)
4.	Melatonin
5.	Daunorubicin (Cerubidine)
6.	7,8-dihydromethysticin
7.	3-(indol-3-yl)propionic acid

Related Therapies and Procedures

1.	Oral Administration