2-hexynyladenosine-5'-N-ethylcarboxamide

adenosine receptor agonist

Also Known As:

2-hexynyl-5'-N-ethylcarboxamidoadenosine; 2-hexynyl-NECA; HENECA

Networked: 6 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        Adenosine-5'-(N-ethylcarboxamide): 202
        2-hexynyladenosine-5'-N-ethylcarboxamide: 6
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - Adenosine-5'-(N-ethylcarboxamide): 202
        2-hexynyladenosine-5'-N-ethylcarboxamide: 6
  - Ribonucleosides: 49
    - Adenosine: 12431
      - Adenosine-5'-(N-ethylcarboxamide): 202
        2-hexynyladenosine-5'-N-ethylcarboxamide: 6

Experts

1.	Bonda, Tomasz A: 1 article (03/2021)
2.	Karolczak, Kamil: 1 article (03/2021)
3.	Kramkowski, Karol: 1 article (03/2021)
4.	Polak, Dawid: 1 article (03/2021)
5.	Przygodzki, Tomasz: 1 article (03/2021)
6.	Talar, Marcin: 1 article (03/2021)
7.	Watala, Cezary: 1 article (03/2021)
8.	Wojkowska, Dagmara W: 1 article (03/2021)
9.	Wolska, Nina: 1 article (03/2021)
10.	Bian, Jin-Song: 1 article (01/2014)

Related Diseases

1.	Thrombosis (Thrombus) 03/17/2021 - "We have found that a selective A2A agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine (HE-NECA) improved the anti-thrombotic properties of either cangrelor or prasugrel in the model of ferric chloride-induced experimental thrombosis in mice. "
2.	Seizures (Absence Seizure) 12/29/1995 - "The protective effects of the selective adenosine A1 receptor agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA), the selective adenosine A2A receptor agonist, 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA), and the non-selective agonist, 5'-N-ethylcarboxamidoadenosine (NECA) were studied against lethal seizures induced by intraperitoneal (i.p.) injection of pentylenetetrazole (80 mg/kg). "
3.	Tachycardia (Tachyarrhythmias) 04/01/1995 - "The A2a agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine induced dose-related hypotension (eg, 0.003 mg/kg; peak, -36 mm Hg; time to peak, 0.32 hour) with reflex tachycardia (eg, 0.003 mg/kg; peak, 152 bpm; time to peak, 0.35 hour). " 04/01/1998 - "In normotensive rats, SCH 58261, at 10 mg/kg i.p., significantly (P < .05) inhibited hypotension and tachycardia induced by the A2A receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine (0.01 mg/kg i.p.), but not the bradycardic effect caused by the A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (0.03 mg/kg i.p.). "
4.	Hypotension (Low Blood Pressure) 04/01/1995 - "The A2a agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine induced dose-related hypotension (eg, 0.003 mg/kg; peak, -36 mm Hg; time to peak, 0.32 hour) with reflex tachycardia (eg, 0.003 mg/kg; peak, 152 bpm; time to peak, 0.35 hour). " 04/01/1998 - "In normotensive rats, SCH 58261, at 10 mg/kg i.p., significantly (P < .05) inhibited hypotension and tachycardia induced by the A2A receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine (0.01 mg/kg i.p.), but not the bradycardic effect caused by the A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (0.03 mg/kg i.p.). "
5.	Reperfusion Injury 01/01/1997 - "We investigated the effects of the selective A1 adenosine receptor agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), the selective A2A adenosine receptor agonists, 2-[p-(2-carboxyethyl)phenetylamino]-5'-N-ethylcarboxamidoadenosine (CGS 21680), 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA), and the non selective agonist, 5'-N-ethylcarboxamidoadenosine (NECA), on ischemia-reperfusion injury in Langendorff-perfused rat hearts. "

Related Drugs and Biologics

1.	Adenosine-5'-(N-ethylcarboxamide) (NECA)
2.	Adenosine A2A Receptor (Adenosine A2A Receptors)
3.	Adenosine A1 Receptor
4.	Pentylenetetrazole (Metrazol)
5.	Prasugrel Hydrochloride
6.	cangrelor
7.	ferric chloride
8.	Purinergic P1 Receptor Agonists
9.	Amyloid Precursor Protein Secretases (beta-Secretase)
10.	Purinergic P1 Receptors (Adenosine Receptor)