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5,5'-dihydroxy-4,4'-bitryptamine

structure given in first source

Also Known As:

DHBT

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Biogenic Amines: 992
    - Biogenic Monoamines: 29
      - Tryptamines: 1679
        5,5'-dihydroxy-4,4'-bitryptamine: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        5,5'-dihydroxy-4,4'-bitryptamine: 5

Experts

1.	Bae, Hyeon-Min: 1 article (01/2018)
2.	Choi, Jong-Kwan: 1 article (01/2018)
3.	Choi, Mingyu: 1 article (01/2018)
4.	Hwang, Gunpil: 1 article (01/2018)
5.	Ji, Minsu: 1 article (01/2018)
6.	Kim, Jae-Myoung: 1 article (01/2018)
7.	Ko, Sang-Bae: 1 article (01/2018)
8.	Angeloni, Cristina: 1 article (08/2008)
9.	Ravaioli, Giulia: 1 article (08/2008)
10.	Rodriguez-Mateos, Ana: 1 article (08/2008)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/1992 - "These observations suggest that if DHBT is formed as an aberrant metabolite of 5-HT in the human brain, it could potentially be neurotoxic and contribute to the neuronal degeneration and other neurochemical and neurobiochemical changes associated with AD or perhaps other neurodegenerative diseases." 11/01/1997 - "One major oxidation product formed under these conditions, the 5-HT dimer 5,5'-dihydroxy-4,4'-bitryptamine (DHBT), was suggested to have neurotoxic properties and to contribute to neuronal damage in neurodegenerative disorders. "
2.	Parkinson Disease (Parkinson's Disease) 10/01/1997 - "Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease." 08/15/2008 - "Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols."
3.	Orthostatic Intolerance 01/01/2018 - "Although the absolute levels and the variations of systolic and diastolic BPs and mean arterial pressure showed no significant difference between the two groups, the proposed model showed a distinct difference in slope variation and response time of DHbT between the subjects with frequent symptom of orthostatic intolerance and the healthy control subjects. "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	5,5'-dihydroxy-4,4'-bitryptamine
3.	Polyphenols
4.	Peroxynitrous Acid (Peroxynitrite)
5.	Neurotoxins
6.	Endotoxins
7.	Acids