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Ro 19-8022
structure given in first source
Also Known As:
1-((10-chloro-4-oxo-3-phenyl-4H-benzo(a)quinolizin-1-yl)carbonyl)-2-pyrrolidine methanol; Ro-19-8022
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrrolidines: 115
Ro 19-8022: 7
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolizines: 1
Ro 19-8022: 7
Experts
1.
Kubová, H
: 2 articles (01/2012 - 01/2011)
2.
Mareš, P
: 2 articles (01/2012 - 01/2011)
3.
Mikulecká, A
: 1 article (01/2011)
4.
Krsiak, M
: 1 article (04/2000)
5.
Podhorna, J
: 1 article (04/2000)
Related Diseases
1.
Seizures (Absence Seizure)
01/01/2011 - "
Similar effects of Ro 19-8022 on PTZ-induced seizures and ultrasonic vocalizations were observed 24 and 48 hours after administration; motor performance was not affected.
"
11/01/1999 - "
On the contrary, incidence of minimal seizures was significantly increased by Ro 19-8022 in 7-and 12-day-old rat pups.
"
11/01/1999 - "
The other types of seizures (minimal clonic) induced by PTZ were suppressed by Ro 19-8022 only in 18-day-old and older rats in which PTZ reliably elicited these types of seizures.
"
11/01/1999 - "
Ro 19-8022 exhibited an excellent anticonvulsant action especially against generalized tonic-clonic seizures; this action was lost with very high doses.
"
11/01/1999 - "
The benzodiazepine receptor partial agonist Ro 19-8022 suppresses generalized seizures without impairing motor functions in developing rats.
"
2.
Ataxia (Dyssynergia)
04/01/2000 - "
Thus, Ro 19-8022 produces anxiolytic-like and potent anti-aggressive effects without causing muscle relaxation or ataxia in the present model.
"
01/01/1998 - "
Ro 19-8022 (10 mg/kg) significantly antagonized the decrease of social behavior and the increase of aggression after alprazolam withdrawal without causing sedation or ataxia.
"
3.
Substance Withdrawal Syndrome (Withdrawal Symptoms)
01/01/2012 - "
There is a difference between immature and adult brain in an appearance of withdrawal symptom after administration of the partial agonist of benzodiazepine receptors Ro 19-8022.
"
01/01/2012 - "
Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats.
"
4.
Anxiety Disorders (Anxiety Disorder)
09/01/1992 - "
Taken together, such preclinical data suggest that benzodiazepine receptor partial agonists with a neurological and behavioral profile such as that of Ro 19-8022 may offer an innovative therapeutic approach to the treatment of anxiety disorders.
"
Related Drugs and Biologics
1.
GABA-A Receptors (GABA(A) Receptor)
2.
Pentylenetetrazole (Metrazol)
3.
Anti-Anxiety Agents (Anxiolytics)
4.
Anticonvulsants (Antiepileptic Drugs)
5.
Triazolam (Halcion)
6.
Ligands
7.
Hypnotics and Sedatives (Sedatives)
8.
Diazepam (Valium)
9.
Convulsants
10.
Alprazolam (Xanax)