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9-deaza-9-(3-thienylmethyl)guanine

Also Known As:

CI 1000; CI-1000; PD 141955; PD-141955

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        9-deaza-9-(3-thienylmethyl)guanine: 5

Experts

1.	Korthals Altes, Hester: 1 article (01/2018)
2.	McDonald, Scott A: 1 article (01/2018)
3.	Postma, Maarten J: 1 article (01/2018)
4.	Tulen, Anna D: 1 article (01/2018)
5.	Wallinga, Jacco: 1 article (01/2018)
6.	de Melker, Hester E: 1 article (01/2018)
7.	van Wijhe, Maarten: 1 article (01/2018)
8.	Cheng, Yanli: 1 article (06/2016)
9.	Fan, Songmiao: 1 article (06/2016)
10.	Kang, Chuyun: 1 article (06/2016)

Related Diseases

1.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 03/01/1994 - "To elucidate the potential use of PNP inhibitors in the therapy of cutaneous T-cell lymphomas (CTCLs) the authors studied the effects of CI-1000 (formerly PD141955-2) and CI-972 on a T-cell line MyLa established from a patient with mycosis fungoides. "
2.	T-Cell Leukemia (Leukemia, T Cell) 10/01/1997 - "To examine the involvement of apoptosis in T-cells following PNP inhibition, MOLT-4 cells, a human T cell leukemia cell line, were co-treated with the PNP inhibitor, CI-1000 (2-amino 3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]-pyrimidin-4-one HCl), and 2'-deoxyguanosine (dGuo) which resulted in a concentration-dependent loss of cell viability (trypan blue) and inhibition of tritiated thymidine ([3H]-TdR) uptake. "
3.	Poliomyelitis (Polio) 01/01/2018 - "In the first 13 years of mass vaccinations, case notifications declined rapidly with 18,900 (95%-CI: 12,000-28,600) notified cases of diphtheria averted, 5100 (95%-CI: 2200-13,500) cases of poliomyelitis, and 1800 (95%-CI: 1000-3200) cases of mumps. "
4.	Mycosis Fungoides 03/01/1994 - "To elucidate the potential use of PNP inhibitors in the therapy of cutaneous T-cell lymphomas (CTCLs) the authors studied the effects of CI-1000 (formerly PD141955-2) and CI-972 on a T-cell line MyLa established from a patient with mycosis fungoides. "
5.	Mumps 01/01/2018 - "In the first 13 years of mass vaccinations, case notifications declined rapidly with 18,900 (95%-CI: 12,000-28,600) notified cases of diphtheria averted, 5100 (95%-CI: 2200-13,500) cases of poliomyelitis, and 1800 (95%-CI: 1000-3200) cases of mumps. "

Related Drugs and Biologics

1.	Trypan Blue
2.	Thymidine
3.	Methotrexate (Mexate)
4.	CI 972

Related Therapies and Procedures

1.	Therapeutics