12/02/1996 - "Intra-amygdaloid microinjection of 3-aminopropylarsonate (10 nmol in 0.5 microl injection vehicle) inhibited electrical epileptogenesis by keeping the seizure score at or below stage 1 on the Racine scale, and the afterdischarge duration (ADD) at or below 19.70 +/- 4.59 s. "
12/01/1998 - "Chemical reduction of 3-aminopropylarsonate with glutathione diminished the anti-seizure activity of the drug. "
12/02/1996 - "In fully NMDA-kindled rats, intra-amygdala administration of 3-aminopropylarsonate (10 nmol/0.5 microl) 20 min before injection of NMDA (4 nmol/0.5 microl) reduced the seizure score from 3.80 +/- 0.37(5) on the Racine scale to 0.83 +/- 0.40(6) (P < 0.01). "
12/02/1996 - "The effect of 3-aminopropylarsonate was also selective to NMDA receptors since it had no effect on kainate-induced seizures. "
12/02/1996 - "The effects of 3-aminopropylarsonate, an arsono analogue of GABA, was tested on the development of electrically-kindled amygdala and on the expression of generalized seizure activity in electrically and NMDA fully amygdala-kindled rats. "
|2.||N-Methyl-D-Aspartate Receptors (NMDA Receptors)
|3.||Kainic Acid (Kainate)
|4.||Glutathione (Reduced Glutathione)
|5.||gamma-Aminobutyric Acid (GABA)