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di-Calciphor
used to treat brain ischemia
Also Known As:
16,16'-dimethyl prostaglandin B1 dimer; 1-Cyclopentene-1-heptanoic acid, 4-(1-((2-(6-carboxyhexyl)-3-oxo-1-cyclopenten-1-yl)methyl)-3,3-dimethyl-2-oxoheptyl)-2-(4,4-dimethyl-3-oxo-1-octenyl)-5-oxo-
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins B: 230
di-Calciphor: 4
Biological Factors: 2472
Inflammation Mediators: 1113
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Prostaglandins B: 230
di-Calciphor: 4
Related Diseases
1.
Ischemia
03/19/1993 - "
Post-ischemic treatment of di-Calciphor (16,16'-dimethyl-15- dehydroprostaglandin B1) significantly improves animal survival and prevents ischemia-induced neurodegeneration of vulnerable forebrain regions assessed with histochemical and biochemical techniques in gerbils.
"
05/01/1994 - "
Di-Calciphor is a synthetic derivative of prostaglandin B1 that protects against cerebral and cardiac ischemia apparently by preserving mitochondrial function.
"
05/27/1992 - "
Treatment with di-Calciphor injected at 10 mg/kg at 5 min and 24 h post 20 min ischemia substantially reduced the period of postischemic locomotor hyperactivity.
"
2.
Mitochondrial Diseases (Mitochondrial Disease)
05/24/1995 - "
Thus, the results indicate that di-calciphor may represent a new type of mitochondrial protectant that inhibits ion transport and thus slows the loss of osmotic stability and delays mitochondrial dysfunction under traumatic and toxicologic conditions.
"
3.
Brain Ischemia (Cerebral Ischemia)
03/19/1993 - "
Neuroprotective activity of dimer of 16,16'-dimethyl-15-dehydroprostaglandin B1 (di-Calciphor) in cerebral ischemia.
"
Related Drugs and Biologics
1.
Dihydrotachysterol (AT 10)
2.
prostaglandin B1