Amiloride FDA Link Generic

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Also Known As:

Midamor; Amidal; Amiduret Trom; Amiloberag; Amiloride Hydrochloride; Amiloride Hydrochloride, Anhydrous; Kaluril; Midoride; Modamide; Anhydrous Amiloride Hydrochloride; Hydrochloride, Amiloride; Hydrochloride, Anhydrous Amiloride; Trom, Amiduret; Pyrazinecarboxamide, 3,5- diamino- N- (aminoiminomethyl)- 6- chloro-

Pharmalogical Action Categories:

Acid Sensing Ion Channel Blockers
Diuretics
Epithelial Sodium Channel Blockers

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - Amiloride: 1400

2'-methoxy-5'-nitrobenzamil

Bio-Agent Context: Research Results