|1.||Potempa, Jan: 6 articles (01/2015 - 03/2005)|
|2.||Kadowaki, Tomoko: 5 articles (11/2006 - 06/2003)|
|3.||Yamamoto, Kenji: 5 articles (11/2006 - 06/2003)|
|4.||Takii, Ryosuke: 4 articles (02/2005 - 06/2003)|
|5.||Baba, Atsuyo: 4 articles (02/2005 - 06/2003)|
|6.||Okuda, K: 3 articles (05/2007 - 05/2001)|
|7.||Ishihara, K: 3 articles (05/2007 - 05/2001)|
|8.||Hashimoto, Munetaka: 3 articles (11/2006 - 06/2003)|
|9.||Tsukuba, Takayuki: 3 articles (11/2006 - 12/2004)|
|10.||Abe, N: 3 articles (05/2001 - 08/2000)|
01/01/2014 - "Although the ideal gingipain inhibitor has yet to be discovered, gingipain inhibition represents a novel approach to treat and prevent periodontitis. "
10/15/1999 - "This gingipain R structure is an excellent template for the rational design of drugs with a potential to cure and prevent periodontitis. "
07/01/1996 - "The aim of this study is to determine whether either gingival crevicular fluid (GCF) bacterial gingivain/gingipain or dipeptidyl peptidase (DPP) levels, total activity (TA) and concentration (EC), predict progressive attachment loss (AL) in 75 patients with moderate periodontitis. "
12/01/2013 - "Protease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced by Porphyromonas gingivalis and by neutrophil protease 3 (P3). "
09/15/2009 - "Porphyromonas gingivalis, a Gram-negative bacterium that causes periodontitis, activates the kinin system via the cysteine protease R-gingipain. "
09/15/2009 - "gingivalis W83 (wild type), but not gingipain-deficient mutant or wild-type bacteria pretreated with gingipain inhibitors, elicited buccal edema and gingivitis in BALB/c or C57BL/6 mice. "
01/01/2001 - "In this study, we developed a procedure to produce gingivitis in rats by inoculation of Porphyromonas gingivalis and studied the contribution of the bacterial cysteine proteinases, Arg-gingipain (Rgp) and Lys-gingipain (Kgp), to the pathology in the gingiva. "
|5.||Periodontal Diseases (Periodontal Disease)
01/01/2013 - "Arg-specific gingipain (Rgp) is a major pathogenic determinant of Porphyromonas gingivalis which is a major pathogen in periodontal disease. "
12/01/1997 - "gingivalis) has been implicated as an important pathogen in periodontal diseases, and its protease (Arg-gingipain) is one of the most important disease-causing factors. "
01/01/2015 - "K6F present in the gingival crevicular fluid of periodontal disease patients and in gingipain-treated rat gingival epithelial cell culture supernatants was measured by matrix-assisted laser desorption/ionization time-of-flight mass spectrometer-based rapid quantitative peptide analysis using BLOTCHIP. "
09/11/1998 - "This response by neutrophils to gingipain-R may be a mechanism for the development of inflammation associated with periodontal disease."
10/01/2005 - "Gingipain-specific IgG in the sera of patients with periodontal disease is necessary for opsonophagocytosis of Porphyromonas gingivalis."
|1.||Cysteine Proteases (Cysteine Protease)
|2.||Lys-gingipain (gingipain K)
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|5.||DNA (Deoxyribonucleic Acid)
|7.||A-Form DNA (A-DNA)
|8.||Virulence Factors (Pathogenicity Factors)
|9.||Proteins (Proteins, Gene)
|10.||Peptide Hydrolases (Proteases)