glutaryl-2-(hydroxymethyl)anthraquinone

Also Known As:

2-(hydroxymethyl)anthraquinone-hemiglutarate; G-HMAQ

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        Anthrones: 12
        Anthraquinones: 788
        glutaryl-2-(hydroxymethyl)anthraquinone: 3
- Quinones: 434
  - Anthraquinones: 788
    - glutaryl-2-(hydroxymethyl)anthraquinone: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        glutaryl-2-(hydroxymethyl)anthraquinone: 3

Related Diseases

1.	Neoplasms (Cancer) 01/01/1996 - "Both T-98 and [D-Lys6]LH-RH significantly inhibited the growth of MXT cancers, but G-HMAQ had only a minor non-significant effect. " 01/01/1993 - "Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition. " 04/01/1992 - "Cytotoxic luteinizing hormone-releasing hormone (LH-RH) analogs, AJ-004 (agonist [D-Lys6]LH-RH linked to methotrexate (MTX)), T-98 ([D-Lys6]LH-RH coupled to glutaryl-2-(hydroxymethyl)anthraquinone) (G-HMAQ) and T-121/B (antagonist containing two residues of G-HMAQ) were tested in female BDF1 mice bearing MXT ((3.2)/Ovex) estrogen-independent mammary tumors. "
2.	Breast Neoplasms (Breast Cancer) 01/01/1993 - "Binding capacities and apparent dissociation constants of receptors for luteinizing-hormone-releasing hormone (LHRH) were investigated in estrogen-independent MXT mammary cancers of untreated mice and after in vivo treatment with agonistic or antagonistic analogs of LHRH containing cytotoxic radicals: AJ-04 (agonist [D-Lys6]LHRH linked to methotrexate), T-98-([D-Lys6]LHRH coupled to glutaryl-2-(hydroxmethyl)anthraquinone (G-HMAQ)) and T-121/B (LHRH antagonist T-147 containing two residues of G-HMAQ), which induced tumor growth inhibition. "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	lysine(6)- glutaryl- 2- (hydroxymethyl)anthraquinone LHRH (T 98)
3.	Methotrexate (Mexate)
4.	Estrogens (Estrogen)
5.	Anthraquinones
6.	ovex