atevirdine

inhibits replication of HIV-1; U 87201E is the methanesulfonate salt

Also Known As:

U 87201; U 87201E; U-87201; U-87201E; atevirdine mesylate; Piperazine, 1-(3-(ethylamino)-2-pyridinyl)-4-((5-methoxy-1H-indol-2-yl)carbonyl)-

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - atevirdine: 6

Experts

1.	Abdel-Lateff, Ahmed: 1 article (01/2021)
2.	Abdul-Hameed, Zainab H: 1 article (01/2021)
3.	Alarif, Walied M: 1 article (01/2021)
4.	Alotaibi, Modhi O: 1 article (01/2021)
5.	Bawakid, Nahed O: 1 article (01/2021)
6.	Mohammed, Afrah E: 1 article (01/2021)
7.	Sobahi, Tariq R: 1 article (01/2021)
8.	Bassiakos, Y: 1 article (01/2000)
9.	Batts, D: 1 article (01/2000)
10.	Cox, S: 1 article (01/2000)

Related Diseases

1.	AIDS Dementia Complex 10/01/1996 - "Pilot study of the efficacy of atevirdine in the treatment of AIDS dementia complex." 10/01/1996 - "To determine the efficacy of the non-nucleoside reverse transcriptase inhibitor atevirdine in the treatment of AIDS dementia complex (ADC). "
2.	HIV Infections (HIV Infection) 01/01/2000 - "Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. " 02/01/1995 - "Additional studies should be done to determine the role of atevirdine in the therapy for HIV infection."
3.	Infections 03/01/1996 - "Didanosine reduces atevirdine absorption in subjects with human immunodeficiency virus infections." 02/01/1995 - "Phase I study of atevirdine, a nonnucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type 1 infection. " 02/01/1995 - "Twenty patients were enrolled in a phase I clinical trial of atevirdine, a nonnucleoside reverse transcriptase inhibitor (NNRTI), given in combination with zidovudine for treatment of human immunodeficiency virus type 1 (HIV-1) infection. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2000 - "Two open label, phase I studies conducted by the adult AIDS Clinical Trials Group (ACTG) in which atevirdine was administered every 8 h with weekly dosage adjustments to attain targeted trough plasma atevirdine concentrations. " 08/01/1993 - "These data suggest that the interaction of atevirdine with HIV-1 RT is different than that of other nonnucleoside RT inhibitors and that combinations of atevirdine and zidovudine may be useful in patients with AIDS who have initially received monotherapy with zidovudine."
5.	Erectile Dysfunction 01/18/2021 - "Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc. Monoterpene Indole Alkaloids (MIAs) deserve the curiosity and attention of researchers due to their chemical diversity and biological activities. "

Related Drugs and Biologics

1.	Reverse Transcriptase Inhibitors
2.	Nucleosides
3.	Zidovudine (Retrovir)
4.	Secologanin Tryptamine Alkaloids (Alseroxylon)
5.	Didanosine (Videx)
6.	Yohimbine (Yocon)
7.	Vincristine (Oncovin)
8.	Vincamine
9.	Vinblastine (Vinblastine Sulfate)
10.	Vasodilator Agents (Vasodilators)

Related Therapies and Procedures

1.	Therapeutics