alpha-galactosyl epitope

used as an endothelial and epithelial marker in canine tissues; binds Evonymus europaeus agglutinin (EEA) in endothelial cells

Also Known As:

GAS914; Galalpha1-3Galbeta1-4GlcNAc-R; alpha-Gal(1-3)-beta-Gal(1-4)-GlcNAc; alpha-Gal(1-3)-beta-Gal(1-4)-GlcNAc-R; galili epitope

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Trisaccharides: 123
      - alpha-galactosyl epitope: 8

Experts

1.	Bello-Gil, Daniel: 1 article (02/2017)
2.	Costa, Cristina: 1 article (02/2017)
3.	Mañez, Rafael: 1 article (02/2017)
4.	Pérez-Cruz, Magdiel: 1 article (02/2017)
5.	Qiu, Ying: 1 article (08/2013)
6.	Wang, Yi Zhong: 1 article (08/2013)
7.	Xu, Ming Bao: 1 article (08/2013)
8.	Yun, Mark M: 1 article (08/2013)
9.	Yun, Sheng: 1 article (08/2013)
10.	Brevig, T: 1 article (01/2001)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2001 - "In the present study, our aim was to determine whether a pretreatment with antibodies against the alpha-galactosyl epitope (anti-Gal) and complement would lyse or otherwise damage dopaminergic neurons in porcine embryonic ventral mesencephalon (VM), the donor tissue for treatment of Parkinson's disease by xenotransplantation. "
2.	Graves Disease (Basedow Disease) 01/01/1991 - "To study this possibility, alpha-galactosyl epitope expression on thyroid cell membranes of normal individuals and patients with Graves' disease was assessed by a sensitive radioimmunoassay. "
3.	Neoplasms (Cancer) 09/01/1997 - "The effects of the alpha-galactosyl epitope found in these CHOs on the immunological properties of the immunoconjugates as efficient cancer diagnostics and therapeutics are being studied." 12/01/1995 - "Developing methods for in vitro synthesis of the carbohydrate structure Galalpha1-3Galbeta1-4GlcNAc-R (termed the alpha-galactosyl epitope) on human tumour cells may be of potential clinical significance in cancer immunotherapy. "
4.	Sepsis (Septicemia) 02/01/2017 - "However, the removal of anti-αGal antibodies in Gal-KO mice with GAS914 in the context of sepsis after cecal ligation and puncture (CLP) was associated with a significant increase in the production of leptin, CXLC1, CXLC13, and TIMP-1 cytokines compared to vehicle (PBS)-treated controls. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2013 - "Pancreatic carcinoma-specific immunotherapy using synthesised alpha-galactosyl epitope-activated immune responders: findings from a pilot study."

Related Drugs and Biologics

1.	Antibodies
2.	Complement System Proteins (Complement)
3.	Carbohydrates
4.	Epitopes
5.	alpha-galactosyl epitope
6.	Lectins
7.	Leptin
8.	Tissue Inhibitor of Metalloproteinase-1
9.	Immunoconjugates (Immunoconjugate)
10.	Cytokines

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy
3.	Therapeutics
4.	Punctures
5.	Ligation