kalinin

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463 relevant articles (9 outcomes, 58 trials/studies) found for this Bio-Agent

Description: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments; consists of 3 subunits, kalinin A, B2, & B1; amino acid sequence has been determined; RefSeq NM_000228 (human), NM_008484 (mouse)

Also Known As:

BM 600; BM-600; BM600-125kDa protein, human; LAMB3 protein; LAMB3 protein, human; LAMNB1 protein, human; Lamb3 protein, mouse; epiligrin; kalinin B1; kalinin B1 chain protein, human; laminin 332; laminin 5; laminin 5 beta 3 protein, human; laminin B1k; laminin B1k chain protein, human; laminin, beta 3 protein, human; laminin, beta 3 protein, mouse; laminin-332 gamma 2 chain, human; laminin-5; laminin-5 beta3 protein; nicein; nicein protein, mouse

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Glycoproteins: 14707

Membrane Glycoproteins: 1543

Cell Adhesion Molecules: 1503

kalinin: 463

Membrane Proteins: 4125

Membrane Glycoproteins: 1543

Cell Adhesion Molecules: 1503

kalinin: 463

Biological Factors: 931

Antigens: 95584

Surface Antigens: 3817

Cell Adhesion Molecules: 1503

kalinin: 463

Experts

1.	Miyazaki, Kaoru: 7 articles (05/2007 - 01/2002)
2.	Auer, G: 7 articles (11/2005 - 01/2001)
3.	Yancey, Kim B: 6 articles (01/2008 - 04/2003)
4.	Hirohashi, Setsuo: 6 articles (09/2004 - 01/2002)
5.	Hashimoto, Takashi: 5 articles (01/2008 - 11/2003)
6.	Berndt, Alexander: 5 articles (06/2007 - 01/2003)
7.	Kosmehl, Hartwig: 5 articles (06/2007 - 01/2003)
8.	Giannelli, G: 5 articles (01/2007 - 01/2000)
9.	Sorsa, Timo: 5 articles (01/2007 - 01/2003)
10.	Lazarova, Z: 5 articles (11/2006 - 01/2000)

Related Diseases

1.	Blister (Bulla) 04/01/2000 - "These studies demonstrated that neither complement activation nor cross-linking of laminin 5 in epidermal basement membranes was required for induction of subepidermal blister formation in this animal model of a human autoimmune bullous disease." 08/01/2000 - "Basement membrane components were atypically deposited and, at least in the case of laminin-5, improperly processed, leading to disruption of the basement membrane and blister formation at the dermal-epidermal junction. " 03/01/1998 - "In 4-day-old blisters, about 20-50 cells at the leading edge of the migrating tongue showed cytoplasmic laminin-5 immunostaining. " 05/01/2000 - "Band-like immunostaining in the basement membrane for laminin 5, alpha5 and beta1 chains was continuous in blister bases, but partially discontinuous in open wound bases. " 09/01/2000 - "Remarkably, in the absence of the known laminin-5 binding integrins (alpha3beta1, alpha6beta4, and alpha6beta1), keratinocytes retained the capacity to proliferate in the epidermis, and epidermal stratification and skin morphogenesis appeared normal prior to blister formation. " Order ALL the reference details at left...
2.	Neoplasms (Cancer) 03/01/2008 - "Further study of other basal-like tumors for laminin 5 expression is warranted to determine the usefulness of laminin 5 in their diagnosis." 03/01/2007 - "Recent studies have shown that laminin-5 (LN-5), a major component of the epithelial basement membrane, plays a more active role in cell migration or tumor invasion. " 04/01/2005 - "Together with previous studies showing that laminin-5 is involved in the invasive and malignant phenotype of several tumor types, our data suggest that the oncogenic effect of EWS-ETS may be mediated in part by upregulation of LAMB3 expression." 02/01/2005 - "In a further study, the degree of budding, which was assessed by an immunohistochemical study of gamma2 chain of laminin-5, was closely related to the number and location of isolated tumor cells. " 09/01/2004 - "However, previous studies have not clarified whether laminin 5 beta3 chain is coexpressed with laminin 5 gamma 2 chain in cancer cells. " Order ALL the reference details at left...
3.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 12/01/2008 - "Deficiency of the basement membrane component laminin-5 (LAM5) causes junctional epidermolysis bullosa (JEB), a severe and often fatal skin adhesion defect. " 06/01/2008 - "Junctional epidermolysis bullosa (JEB) is an inherited mechanobullous disease characterized by reduced adherence of the epidermal keratinocytes to the underlying dermis, and is often caused by the absence of functional laminin 332 due to the lack or dysfunction of its beta3 chain. " 01/01/2008 - "Herlitz junctional epidermolysis bullosa: laminin-5 mutational profile and carrier frequency in the Italian population." 12/01/2007 - "Here, we discuss current understanding of the biological functions of laminin-5, the pathogenic impact of its deficiency and implications on molecular approaches towards a therapy of junctional epidermolysis bullosa." 12/01/2007 - "The major contributions of laminin-5 to the resistance of the epidermis against frictional stress but also for basement membrane regeneration and repair of damaged skin are reflected by the phenotype of Herlitz junctional epidermolysis bullosa, which is caused by an inherited absence of functional laminin-5. " Order ALL the reference details at left...
4.	Carcinoma (Carcinomatosis) 03/01/2008 - "Thus laminin 5 may be helpful for making the diagnosis of metaplastic carcinomas in biopsies, allowing the potential for aggressive early treatment. " 09/01/2006 - "In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic migration and inhibits invasion of prostate carcinoma cells on laminin-5. " 01/01/2002 - "The aim of our study was to determine if laminin-5 gamma 2 chain antibody can act as a sensitivity marker of invasive capacity in precancerous and invasive carcinoma in women with uni- and multifocal changes in the anogenital tract. " 10/01/1996 - "Although it is unclear how the gene for the gamma 2 subchain of laminin 5 is regulated, results of this study suggest that there is a post-transcriptional defect in the expression of the gamma 2 subchain that occurs during the progression from a premalignant lesion to invasive carcinoma. " 01/01/2009 - "Ovarian clear cell carcinoma (CCC) characteristically shows stromal accumulation of the basement membrane material laminin-5 (LN-5). " Order ALL the reference details at left...
5.	Wounds and Injuries (Trauma) 06/15/1997 - "These studies also suggest that during reepithelialization of human skin wounds, the secreted laminin-5 stabilizes the migrating keratinocyte to establish the new basement membrane zone." 01/01/2007 - "Upon epidermal wounding, keratinocytes at the wound edge become activated, deposit newly synthesized laminin-5 into the extracellular matrix, and migrate into the wound bed. " 11/01/2005 - "We have found that, in vivo, p16 is expressed by epidermal and oral keratinocytes at the migrating fronts of healing wounds and at the stromal interface of severely dysplastic and early invasive lesions and that such cells also invariably display increased expression of Laminin 5 (Lam5). " 12/01/2004 - "In particular, the staining pattern of laminin-5 at the wound site was altered. " 11/01/2004 - "The increased laminin 5 protein in the wound area presumably enhances wound repair by stimulating adhesion and migration of keratinocytes on the wound bed and by facilitating basement membrane formation at the dermal-epidermal junction." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Integrin alpha6beta4
2.	Integrin alpha6
3.	Hematoxylin (Haematoxylon)
4.	Eosine Yellowish-(YS) (Eosin)
5.	Matrix Metalloproteinase 7 (Matrilysin)
6.	DNA (Deoxyribonucleic Acid)
7.	Cyclin A
8.	gefitinib (Iressa)
9.	kalinin
10.	Autoantibodies

Related Therapies and Procedures

1.	Ligation
2.	Transplants (Transplant)
3.	Excimer Lasers
4.	Heterologous Transplantation (Xenotransplantation)
5.	Transplantation (Transplant Recipients)

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