L 687306

structure given in first source; a partial agonist at muscarinic M1 receptors; a highly competitve antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors

Also Known As:

3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo(2.2.1)heptane; L 687,306; L-687,306; L-687306; 1-Azabicyclo(2.2.1)heptane, 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-, exo-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        L 687306: 2
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - L 687306: 2

Related Diseases

Ganglion Cysts (Ganglion)

01/01/1993 - "Synthesis of compounds with even lower predicted efficacy, such as the cyclopropyloxadiazole L-687,306 (NMS/Oxo-M ratio 15), maintained agonist activity in the ganglion, but showed antagonist activity in the M3 ileal, as well as the M2 atrial preparations. "
04/29/1992 - "L-687,306 was a partial agonist at muscarinic M1 receptors in the rat ganglion but a high affinity competitive antagonist at guinea-pig cardiac M2 and ileal M3 muscarinic receptors. "

Related Drugs and Biologics

1.	Muscarinic M1 Receptor
2.	Muscarinic M3 Receptor