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methoxyresorufin-O-demethylase

a monooxygenase that is supported by both P4501A1 and P4501A2
Also Known As:
MROD
Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Aksenov, I V: 2 articles (01/2014 - 01/2014)
2. Guseva, G V: 2 articles (01/2014 - 01/2014)
3. Kravchenko, L V: 2 articles (01/2014 - 01/2014)
4. Trusov, N V: 2 articles (01/2014 - 01/2014)
5. Nebert, Daniel W: 2 articles (05/2009 - 02/2003)
6. Chatuphonprasert, Waranya: 1 article (01/2016)
7. Jarukamjorn, Kanokwan: 1 article (01/2016)
8. Sithithaworn, Paiboon: 1 article (01/2016)
9. Udomsuk, Latiporn: 1 article (01/2016)
10. Avrent'eva, L I: 1 article (01/2014)

Related Diseases

1. Avitaminosis (Vitamin Deficiency)
2. Body Weight (Weight, Body)
02/15/2005 - "Propiconazole significantly induced both pentoxyresorufin O-dealkylation (PROD) and methoxyresorufin O-dealkylation (MROD) activities in both rat and mouse liver at the 150 mg/kg body weight/day and 75 mg/kg body weight/day doses. "
01/01/2014 - "Supplementation of the ration with eicosapentaenoic and docosahexaenoic ω-3 polyunsaturated fatty acids (PUFA) in doses of 0.3 and 1 g/kg body weight for 4 weeks had no effect on ethoxyresorufin O-dealkylase (EROD) activity and expression of the CYP1A1 gene in male Wistar rats, but caused a dose-dependent increase in methoxyresorufin O-dealkylase (MROD) activity of CYP1A2 (by 28 and 73%, respectively) without significant changes in CYP1A2 mRNA expression. "
12/01/2000 - "Intraperitoneal administration of ABZ (50 mg/kg body weight/day/three days in corn oil) to rats, caused an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity. "
06/11/1999 - "Increased liver to body weight ratio was present at 100 ppm and increased kidney to body weight ratio at 1000 ppm. Marked increases in hepatic benzoylresorufin O-dealkylase (BROD) and pentoxyresorufin O-dealkylase (PROD) activities were detected starting at 10 ppm. There was a significant decrease in methoxyresorufin O-dealkylase (MROD) activity at 1000 ppm. Hepatic UDP-glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST) activities also increased starting at 100 ppm. A marked increase in urinary excretion of ascorbic acid was apparent starting at 10 ppm, while there were no changes in urinary N-acetylglucosaminidase (NAG) activity and protein levels. "
3. Hepatocellular Carcinoma (Hepatoma)
4. Infections
5. Hyperoxia

Related Drugs and Biologics

1. Enzymes
2. NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
3. Vitamin A (Retinol)
4. Uridine Diphosphate (UDP)
5. Transferases
6. Cytochrome P-450 CYP1A1 (CYP1A1)
7. methoxyresorufin-O-demethylase
8. Cytochrome P-450 CYP1A2 (CYP1A2)
9. Cytochrome P-450 CYP2B1 (PROD)
10. Mixed Function Oxygenases (Monooxygenases)