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connexin 30.3

gap junction gene product found on chromosome 4 & preferentially expressed in skin

Also Known As:

GJB4 protein

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Connexins: 2085
        connexin 30.3: 10

Experts

1.	Lai, Ting-Wei: 1 article (01/2020)
2.	Li, Shuan-Yow: 1 article (01/2020)
3.	Su, Ching-Chyuan: 1 article (01/2020)
4.	Su, Hsuan-An: 1 article (01/2020)
5.	Su, Tzu-Rong: 1 article (01/2020)
6.	Yang, Jiann-Jou: 1 article (01/2020)
7.	Fu, HaiRong: 1 article (01/2019)
8.	Liu, GuiYuan: 1 article (01/2019)
9.	Pang, Yi: 1 article (01/2019)
10.	Xiong, Wei: 1 article (01/2019)

Related Diseases

1.	Erythrokeratodermia Variabilis 03/27/2013 - "Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis." 03/01/2012 - "Erythrokeratodermia variabilis: report of two cases and a novel missense variant in GJB4 encoding connexin 30.3." 11/01/2000 - "Mutation in the gene for connexin 30.3 in a family with erythrokeratodermia variabilis." 12/15/2003 - "Molecular interaction of connexin 30.3 and connexin 31 suggests a dominant-negative mechanism associated with erythrokeratodermia variabilis."
2.	Carcinogenesis 01/01/2019 - "Gap junction beta-4 protein (GJB4), or connexin 30.3, a member of integral membrane proteins, has been shown to involve and may function as a tumor promoter in tumorigenesis. "
3.	Hearing Loss (Hearing Impairment) 04/01/2002 - "These GJB4 variants should help to define the putative role of connexin 30.3 in both skin disorders and hearing impairment." 04/01/2002 - "A common frameshift mutation and other variants in GJB4 (connexin 30.3): Analysis of hearing impairment families."
4.	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 02/01/2005 - "Mutations in connexin 31 (GJB3) and connexin 30.3 (GJB4), implicated in previous reports of EKV, and connexin 26 (GJB2), implicated in palmoplantar keratoderma, were unlikely given the lack of shared homozygous haplotypes in the regions surrounding these genes. "
5.	Hypertension (High Blood Pressure) 05/01/2008 - "Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure."

Related Drugs and Biologics

1.	Connexin 26
2.	human GJB3 protein
3.	Connexin 43 (Connexin43)
4.	Salts
5.	Proteins (Proteins, Gene)
6.	Membrane Proteins (Integral Membrane Proteins)
7.	Carcinogens