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amthamine

histamine H2 receptor agonist; structure & RN given in first source; RN given refers to parent cpd

Also Known As:

2-amino-5-(2-aminoethyl)-4-methylthiazole; amthamine dihydrobromide

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - amthamine: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - amthamine: 6

Experts

1.	Chen, Jialu: 1 article (01/2022)
2.	Chen, Zhong: 1 article (01/2022)
3.	Fang, Zhuowen: 1 article (01/2022)
4.	Guo, Yi: 1 article (01/2022)
5.	Hu, Weiwei: 1 article (01/2022)
6.	Lin, Wenkai: 1 article (01/2022)
7.	Tan, Na: 1 article (01/2022)
8.	Wang, Yi: 1 article (01/2022)
9.	Xu, Lingyu: 1 article (01/2022)
10.	Zheng, Yanrong: 1 article (01/2022)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 03/01/1996 - "Dimaprit (0.1-30 mumol/kg i.v.) did not modify heart rate but caused a modest bradycardia at 100 mumol/kg i.v. Amthamine (1-100 mumol/kg i.v.) induced a dose-dependent tachycardia, which was only partially (approximately 20%) reduced by famotidine and was totally blocked by propranolol (0.3 mg/kg i.v.). "
2.	Obesity 01/01/2022 - "Importantly, chronic activation of H2Rs in MS glutamatergic neurons (with its clinical agonist amthamine) significantly slowed down the body-weight gain in DIO mice, providing a possible clinical utility to treat obesity. "
3.	Neoplasms (Cancer) 01/01/2016 - "We further demonstrate that amthamine-induced proliferation in Leydig MA-10 tumor cells, is enhanced by LY294002, a PI3K inhibitor. "
4.	Inflammation (Inflammations) 12/09/2020 - "The combination of amthamine and JNJ-39758979 reduced skin inflammation even more pronounced, diminished epidermal hyperproliferation, and inhibited spontaneous scratching behaviour. "
5.	Hypertrophy 12/01/2018 - "Hypertrophy of cultured cardiac cells upon exposure to histamine and the H2R agonist amthamine substantiates the role of histamine in cardiac remodeling. "

Related Drugs and Biologics

1.	Dimaprit
2.	Famotidine (Pepcid)
3.	Propranolol (Inderal)
4.	Histamine (Histamine Dihydrochloride)
5.	Acids
6.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one