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5- (N,N- bis(2- chloroethyl)amino)- 2,4- dinitrobenzamide

RN & structure given in first source

Also Known As:

SN 23862; SN-23862

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        Aniline Mustard: 12
        5-(N,N-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide: 3

Experts

1.	Denny, William A: 1 article (04/2003)
2.	Helsby, Nuala A: 1 article (04/2003)
3.	Palmer, Brian D: 1 article (04/2003)
4.	Pruijn, Frederik B: 1 article (04/2003)
5.	Wheeler, S James: 1 article (04/2003)
6.	Wilson, William R: 1 article (04/2003)
7.	Yang, Shangjin: 1 article (04/2003)
8.	Kestell, P: 1 article (01/2000)
9.	Palmer, B D: 1 article (01/2000)
10.	Pruijn, F B: 1 article (01/2000)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2000 - "The lesser propensity for SN 23862 to undergo nitroreduction in the host, relative to CB 1954, argues that dinitrobenzamide mustards may be preferable to the corresponding aziridines as bioreductive prodrugs for cancer treatment. "
04/01/2003 - "The dinitrobenzamide aziridine CB 1954 (1) and its nitrogen mustard analogue SN 23862 (6) are prodrugs that are activated by enzymatic nitroreduction in tumors. "
05/15/1994 - "To determine whether 5,6-dimethylxanthenone acetic acid (DMXAA), a potent analogue of flavone acetic acid (FAA) inhibits blood flow in mouse mammary tumors, and to assess whether DMXAA enhances the antitumor effects of Tirapazamine (SR 4233) and the novel bioreductive drug SN 23862 (a dinitrobenbenzene mustard). "

Related Drugs and Biologics

1.	Prodrugs
2.	tretazicar
3.	Acetic Acid (Vinegar)
4.	Mechlorethamine (Nitrogen Mustard)
5.	Aziridines (Ethyleneimines)
6.	Tirapazamine (SR 4233)
7.	vadimezan
8.	flavone acetic acid
9.	aziridine (ethyleneimine)