luffariellolide

structure given in first source; a partially reversible phospholipase A2 inhibitor; a major metabolite of the sponge Luffariella; do not confuse with luffolide, a minor metabolite of the same species

Also Known As:

2(5H)-Furanone, 4-(4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl)-5-hydroxy-, (E,E)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - luffariellolide: 5

Experts

1.	Du, Lin: 1 article (08/2013)
2.	Kelly, Michelle: 1 article (08/2013)
3.	Li, Jun: 1 article (08/2013)
4.	Nagle, Dale G: 1 article (08/2013)
5.	Zhou, Yu-Dong: 1 article (08/2013)
6.	Chen, Jinan: 1 article (08/2012)
7.	Jin, Lihua: 1 article (08/2012)
8.	Jin, Shikai: 1 article (08/2012)
9.	Li, Yong: 1 article (08/2012)
10.	Lin, Shengchen: 1 article (08/2012)

Related Diseases

1.	Edema (Dropsy) 06/01/1989 - "The PLA2 inhibitors, luffariellolide and aristolochic acid, reduced the edema but only when coinjected with the PLA2. " 01/01/1995 - "PMA-induced ear edema was effectively inhibited by scalaradial, luffariellolide and aristolochic acid (ED50 = 70, 50 and 50 micrograms/ear, respectively) whereas ellagic acid was less effective (ED50 = 230 micrograms/ear). "
2.	Neoplasms (Cancer) 08/15/2012 - "Luffariellolide was uncovered as a novel RAR agonist by inducing co-activator binding to these receptors in vitro, further inhibiting cell growth and regulating RAR target genes in various cancer cells. "
3.	Lymphoma (Lymphomas) 11/01/2004 - "Luffariellolide and its 25-O-methyl congener as well as acantholide E (5) were cytotoxic against the mouse lymphoma L5187Y cell line. "
4.	Contact Dermatitis (Eczema, Contact) 01/01/1995 - "In the mouse model of oxazolone contact hypersensitivity, these PLA2 inhibitors have little effect (< or = 30% inhibition at 400 micrograms/ear) with scalaradial and luffariellolide being less effective than either aristolochic or ellagic acid. "
5.	Colonic Neoplasms (Colon Cancer) 08/15/2012 - "Functional characterization further revealed that luffariellolide displays chemotherapeutic potentials for overcoming RA resistance in colon cancer cells, suggesting that luffariellolide may represent a unique template for designing novel non-retinoid compounds with advantages over current RA drugs."

Related Drugs and Biologics

1.	aristolochic acid I (aristolochic acid)
2.	Sesterterpenes
3.	Retinoids
4.	Oxazolone
5.	Ellagic Acid
6.	thorectidaeolide A
7.	4-acetoxythorectidaeolide A
8.	scalaradial
9.	acantholide