S 1108

structure given in first source; an oral cephem antibiotic and prodrug of S-1006

Also Known As:

S-1108; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R-(6alpha,7beta(Z)))-

Networked: 18 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Infections 11/01/1993 - "The results suggest that S-1108 may be a very useful and safe drug for the treatment of pediatric infections." 11/01/1993 - "[Studies on S-1108 in pediatric infection]." 07/01/1995 - "2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. " 12/01/1993 - "[A clinical evaluation of S-1108 in the treatment of pediatric infections]." 11/01/1993 - "[Clinical study on S-1108 in treatment of pediatric infections]."
2.	Urinary Tract Infections (Urinary Tract Infection) 11/01/1993 - "S-1108 was effective in 95% of the 59 examined cases of respiratory, middle ear, skin and urinary tract infections. " 11/01/1993 - "We evaluated the efficacy and safety of S-1108 in 11 children with respiratory tract infections, 3 urinary tract infections, and 2 skin infections. " 11/01/1993 - "3) Clinical studies S-1108 was administered to patients with various pediatrics infections in 34 cases (upper respiratory tract infections: 12 cases, lower respiratory tract infections: 5 cases, urinary tract infections: 9 cases, skin and soft tissue infection: 6 cases, otitis media: 2 cases). " 11/01/1993 - "2. S-1108 was administered to 15 children with various infections (3 patients with pneumonia, 3 with acute bronchitis, 4 with scarlet fever, 2 with acute tonsillitis, 1 with phlegmon and 2 with urinary tract infections). "
3.	Communicable Diseases (Infectious Diseases) 11/01/1993 - "From the above results, we have concluded that S-1108 is a highly effective and safe for patients with various infectious diseases in the pediatric fields." 11/01/1993 - "2. The clinical efficacy of S-1108 was evaluated in 31 patients with various infectious diseases. " 11/01/1993 - "2. Clinical studies S-1108 was administered to 32 patients with various infectious diseases (6 with acute tonsillitis, 2 each with pertussis and acute bronchitis, 3 with pneumonia, 4 with scarlet fever, 5 with impetigo contagiosa, 6 with acute urinary infection and 1 each with subcutaneous abscess, impetigo, vulvitis and urethritis) at daily doses between 6-12 mg/kg/day, t.i.d., for 5-12 days. " 05/01/1993 - "The metabolism and clinical safety of the pivalic acid-containing antibiotic S-1108, an orally active pro-drug cephalosporin, were investigated to assess the clinical effects, with special emphasis on the influence of carnitine consumption in 15 patients with various infectious diseases receiving S-1108 three times a day at a 300- or 600-mg total daily dose for 3 to 7 days. "
4.	Bacterial Infections (Bacterial Infection) 11/01/1993 - "From these data, S-1108 appears to be safe and effective in children with susceptible bacterial infections." 12/01/1993 - "1) Clinical effects of S-1108 against 18 cases of bacterial infections were excellent in 5 cases, good in 10 cases, fair in 1 case and poor in 2 cases, thus the clinical efficacy rates was 83.3%. " 12/01/1993 - "It was concluded the S-1108 was promising drug for the treatment of bacterial infections in children." 12/01/1993 - "S-1108 in a fine granular form was administered in 14 children and its safety and efficacy in bacterial infections were evaluated. " 12/01/1993 - "[Clinical experience with S-1108 on bacterial infection in the pediatric field]."
5.	Staphylococcal Infections 11/01/1993 - "S-1108 was highly effective in infections of Streptococcus pyogenes, Haemophilus influenzae and Escherichia coli, but was less effective in penicillin-resistant Streptococcus pneumoniae and Staphylococcus aureus infections. "

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Prodrugs
4.	Cephalosporins (Cephalosporin Antibiotics)
5.	Carnitine (L-Carnitine)
6.	trichostatin A (A 300)
7.	pivalic acid