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S 1108
structure given in first source; an oral cephem antibiotic and prodrug of S-1006
Also Known As:
S-1108; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R-(6alpha,7beta(Z)))-
Networked:
18
relevant articles (
3
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
beta-Lactams: 2386
Cephalosporins: 4007
S 1108: 18
Sulfur Compounds: 278
Thiazines: 3
Cephalosporins: 4007
S 1108: 18
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
beta-Lactams: 2386
Cephalosporins: 4007
S 1108: 18
Related Diseases
1.
Infections
11/01/1993 - "
The results suggest that S-1108 may be a very useful and safe drug for the treatment of pediatric infections.
"
11/01/1993 - "
[Studies on S-1108 in pediatric infection].
"
07/01/1995 - "
2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections.
"
12/01/1993 - "
[A clinical evaluation of S-1108 in the treatment of pediatric infections].
"
11/01/1993 - "
[Clinical study on S-1108 in treatment of pediatric infections].
"
2.
Urinary Tract Infections (Urinary Tract Infection)
11/01/1993 - "
S-1108 was effective in 95% of the 59 examined cases of respiratory, middle ear, skin and urinary tract infections.
"
11/01/1993 - "
We evaluated the efficacy and safety of S-1108 in 11 children with respiratory tract infections, 3 urinary tract infections, and 2 skin infections.
"
11/01/1993 - "
3) Clinical studies S-1108 was administered to patients with various pediatrics infections in 34 cases (upper respiratory tract infections: 12 cases, lower respiratory tract infections: 5 cases, urinary tract infections: 9 cases, skin and soft tissue infection: 6 cases, otitis media: 2 cases).
"
11/01/1993 - "
2. S-1108 was administered to 15 children with various infections (3 patients with pneumonia, 3 with acute bronchitis, 4 with scarlet fever, 2 with acute tonsillitis, 1 with phlegmon and 2 with urinary tract infections).
"
3.
Communicable Diseases (Infectious Diseases)
11/01/1993 - "
From the above results, we have concluded that S-1108 is a highly effective and safe for patients with various infectious diseases in the pediatric fields.
"
11/01/1993 - "
2. The clinical efficacy of S-1108 was evaluated in 31 patients with various infectious diseases.
"
11/01/1993 - "
2. Clinical studies S-1108 was administered to 32 patients with various infectious diseases (6 with acute tonsillitis, 2 each with pertussis and acute bronchitis, 3 with pneumonia, 4 with scarlet fever, 5 with impetigo contagiosa, 6 with acute urinary infection and 1 each with subcutaneous abscess, impetigo, vulvitis and urethritis) at daily doses between 6-12 mg/kg/day, t.i.d., for 5-12 days.
"
05/01/1993 - "
The metabolism and clinical safety of the pivalic acid-containing antibiotic S-1108, an orally active pro-drug cephalosporin, were investigated to assess the clinical effects, with special emphasis on the influence of carnitine consumption in 15 patients with various infectious diseases receiving S-1108 three times a day at a 300- or 600-mg total daily dose for 3 to 7 days.
"
4.
Bacterial Infections (Bacterial Infection)
11/01/1993 - "
From these data, S-1108 appears to be safe and effective in children with susceptible bacterial infections.
"
12/01/1993 - "
1) Clinical effects of S-1108 against 18 cases of bacterial infections were excellent in 5 cases, good in 10 cases, fair in 1 case and poor in 2 cases, thus the clinical efficacy rates was 83.3%.
"
12/01/1993 - "
It was concluded the S-1108 was promising drug for the treatment of bacterial infections in children.
"
12/01/1993 - "
S-1108 in a fine granular form was administered in 14 children and its safety and efficacy in bacterial infections were evaluated.
"
12/01/1993 - "
[Clinical experience with S-1108 on bacterial infection in the pediatric field].
"
5.
Staphylococcal Infections
11/01/1993 - "
S-1108 was highly effective in infections of Streptococcus pyogenes, Haemophilus influenzae and Escherichia coli, but was less effective in penicillin-resistant Streptococcus pneumoniae and Staphylococcus aureus infections.
"
Related Drugs and Biologics
1.
Penicillins (Penicillin)
2.
Anti-Bacterial Agents (Antibiotics)
3.
Prodrugs
4.
Cephalosporins (Cephalosporin Antibiotics)
5.
Carnitine (L-Carnitine)
6.
trichostatin A (A 300)
7.
pivalic acid