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DS 4574
peptidoleukotriene receptor antagonist used in treatment of hypersensitivity; RN from Chemline for pyrimidin-9(1H)-one cpd
Also Known As:
6-(2-cyclohexylethyl)-(1,3,4)thiadiazolo(3,2-a)-1,2,3-triazolo(4,5-d)pyrimidin-9(3H)-one; DS-4574
Networked:
5
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Triazoles: 1533
DS 4574: 5
Pyrimidines: 510
DS 4574: 5
Related Diseases
1.
Asthma (Bronchial Asthma)
04/01/1993 - "
Therefore, DS-4574 could be useful in the treatment of allergic diseases such as asthma.
"
01/01/1992 - "
These potent activities of DS-4574 in in vivo and in vitro models of immediate-type hypersensitivity reactions suggest that this compound could be useful in the treatment of allergic diseases including asthma.
"
12/01/1992 - "
These findings suggest that DS-4574 is useful for peptic ulcer therapy, as well as for the therapy of various allergic diseases, including asthma.
"
2.
Hypersensitivity (Allergy)
04/01/1993 - "
These results indicate that DS-4574 inhibited type III allergic reactions and some inflammatory reactions.
"
01/01/1992 - "
These potent activities of DS-4574 in in vivo and in vitro models of immediate-type hypersensitivity reactions suggest that this compound could be useful in the treatment of allergic diseases including asthma.
"
3.
Edema (Dropsy)
11/30/1993 - "
Moreover, DS-4574 (10 mg/kg) significantly inhibited both mucosal edema and degranulation of mucosal mast cells.
"
04/01/1993 - "
DS-4574 also had a weak inhibitory activity on carrageenin paw edema in rats, arachidonic acid ear edema in mice and adjuvant arthritis in rats.
"
4.
Stomach Ulcer (Gastric Ulcer)
12/01/1992 - "
Water-immersion restraint stress- and aspirin-induced gastric ulcers were also significantly prevented in a dose-related manner by oral pretreatment with DS-4574 (10-50 mg/kg).
"
5.
Peptic Ulcer (Peptic Ulcers)
12/01/1992 - "
These findings suggest that DS-4574 is useful for peptic ulcer therapy, as well as for the therapy of various allergic diseases, including asthma.
"
Related Drugs and Biologics
1.
Histamine (Histamine Dihydrochloride)
2.
Arachidonic Acid (Vitamin F)
3.
Leukotrienes
4.
Pentagastrin (Peptavlon)
5.
Immunoglobulin E (IgE)
6.
Carrageenan
7.
Carbachol (Carbastat)
8.
Aspirin (Acetylsalicylic Acid)
9.
Antigens
10.
Heterophile Antibodies
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration