pancreatic lipase related protein 2

from human (hPLRP2) & guinea pig (gPLRP2); highly homologous to human pancreatic lipase (hPL), but its lipolytic activity is profoundly different from hPL; amino acid sequence has been determined; RefSeq NM_005396 (human)

Also Known As:

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lowe, Mark E: 3 articles (01/2018 - 07/2009)
2.	Ge, Wenhao: 2 articles (01/2022 - 08/2020)
3.	Xu, Xi: 2 articles (01/2022 - 08/2020)
4.	Yang, Yunxia: 2 articles (01/2022 - 08/2020)
5.	Zhang, Jianfa: 2 articles (01/2022 - 08/2020)
6.	Zhao, Yang: 2 articles (01/2022 - 08/2020)
7.	Carrière, Frédéric: 2 articles (01/2018 - 10/2006)
8.	Alves, Bryce N: 2 articles (09/2009 - 07/2009)
9.	Elliott, Viki: 2 articles (09/2009 - 07/2009)
10.	Hudig, Dorothy: 2 articles (09/2009 - 07/2009)

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2022 - "Liver fibrosis induced by CCl4 or BDL was improved in Plrp2-/- mice. "
2.	Fibrosis (Cirrhosis) 01/01/2022 - "The suppression of pancreatic lipase-related protein 2 ameliorates experimental hepatic fibrosis in mice."
3.	Pancreatitis 10/01/2006 - "Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both HPL and HPLRP2 than the controls subjects. " 01/01/2019 - "The pancreas expresses pancreatic triacylglycerol lipase (PNLIP), pancreatic lipase-related protein 2 (PNLIPRP2), and carboxyl ester lipase (CEL), which may leak into the visceral fat or systemic circulation during pancreatitis. "
4.	Neoplasms (Cancer) 07/01/2009 - "Because PLRP2 in semen can mediate lipid-dependent toxicity to sperm, we questioned whether CTL-derived PLRP2 could support similar cytotoxicity toward tumor cells. " 09/01/2009 - "Cytotoxicity of WT and PLRP2(-/-) CTLs was similar in 2-day tumor survival assays with IL-4, which can be mediated by perforin-independent mechanisms. " 07/01/2009 - "We conclude (1) that lipid-dependent cytotoxicity, promoted by the lipase PLRP2 and colipase, will kill tumor cells and (2) that more than PLRP2 alone is required for lipid-dependent cytotoxicity mediated by CTLs." 07/01/2009 - "Recombinant PLRP2 was toxic to P815 tumor cells in 48 h when lipid and another protein, colipase, were present. "
5.	Chronic Pancreatitis 01/01/2018 - "The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis."

Related Drugs and Biologics

1.	Lipase (Acid Lipase)
2.	Perforin
3.	Octoxynol (Triton X 100)
4.	Interleukin-4 (Interleukin 4)
5.	Proteins (Proteins, Gene)
6.	Lipids
7.	Esters
8.	Bile Acids and Salts (Bile Acids)
9.	Transaminases (Aminotransferases)
10.	Immunomodulating Agents