calanolide A

NSC 661122 and costatolide are isomers; a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum (Clusiaceae); structure in first source

Also Known As:

NSC 661122; calanolide F; costatolide; 2H,6H,10H-Benzo(1,2-b:3,4-b':5,6-b'')tripyran-2-one, 11,12-dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-, (10R-(10alpha,11beta,12alpha))-

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Pyranocoumarins: 12
        calanolide A: 6
    - Pyranocoumarins: 12
      - calanolide A: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Pyranocoumarins: 12
        calanolide A: 6

Experts

1.	Akbar, Idhayadhulla: 1 article (01/2021)
2.	Alfarhan, Ahmed H: 1 article (01/2021)
3.	Chidambaram, Sathishkumar: 1 article (01/2021)
4.	El-Sheikh, Mohamed A: 1 article (01/2021)
5.	Radhakrishnan, Surendrakumar: 1 article (01/2021)
6.	Li, Yan: 1 article (02/2015)
7.	Liu, Xin: 1 article (02/2015)
8.	Liu, Zhihao: 1 article (02/2015)
9.	Mi, Jiaqi: 1 article (02/2015)
10.	Sheng, Li: 1 article (02/2015)

Related Diseases

1.	Infections 11/01/1996 - "Viral life-cycle studies indicated that calanolide A acted early in the infection process, similar to the known HIV reverse transcriptase (RT) inhibitor 2', 3'-dideoxycytidine. "
2.	HIV Infections (HIV Infection) 09/01/1998 - "Both (+)-calanolide A (Cal A; NSC 675451) and (+)-dihydrocalanolide A (DHCal A; NSC 678323) are currently under development for the treatment of HIV infections. " 02/01/2015 - "F18 (10-chloromethyl-11-demethyl-12-oxo-calanolide), an analog of (+)-Calanolide A, is a novel small-molecule nonnucleoside reverse transcriptase inhibitor for the therapy of human immunodeﬁciency virus (HIV) infection. " 01/01/2015 - "In search for more effective drugs against HIV infection acting as non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of new molecules with hybrid structures based on the natural product (+)-calanolide A and the synthetic molecule α-APA, known as potent and selective inhibitors of this enzyme, were selected by docking calculations. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 10/01/1998 - "(+)-Calanolide A, a novel dipyranocoumarin from the Malesian tree Calophyllum lanigerum var. austrocoriaceum, and a closely related compound, (-)-calanolide B, isolated from Calophyllum teysmannii var. inophylloide, are representatives of a distinct class of nonnucleoside HIV-1 specific reverse-transcriptase inhibitor under development as an AIDS chemotherapeutic. "
4.	COVID-19 01/01/2021 - "The recently synthesised compounds were projected conceptual association for COVID-19 protease and also to explore in anticipation if this protein will help target protease inhibitor drugs such as Calanolide A, Cardatolide A, Collinin, Inophyllum A, Mesuol, Isomesuol, Pteryxin, Rutamarin, Seselin and Suksdorin. "

Related Drugs and Biologics

1.	HIV Reverse Transcriptase
2.	Reverse Transcriptase Inhibitors
3.	Proteins (Proteins, Gene)
4.	Protease Inhibitors (Protease Inhibitor)
5.	Peptide Hydrolases (Proteases)
6.	Nucleosides
7.	Enzymes
8.	collinin
9.	seselin
10.	dihydrocalanolide A

Related Therapies and Procedures

1.	Therapeutics