|1.||Hayashi, Hisamitsu: 6 articles (05/2014 - 06/2010)|
|2.||Sugiyama, Yuichi: 4 articles (05/2014 - 09/2010)|
|3.||Nagasaka, Hironori: 4 articles (05/2014 - 06/2010)|
|4.||Ekström, Tomas J: 4 articles (07/2011 - 03/2003)|
|5.||Zeitlin, Pamela L: 4 articles (06/2008 - 07/2002)|
|6.||Kaneko, Masayuki: 3 articles (02/2015 - 10/2004)|
|7.||Okuma, Yasunobu: 3 articles (02/2015 - 10/2004)|
|8.||Nomura, Yasuyuki: 3 articles (02/2015 - 10/2004)|
|9.||Mu, Jiao: 3 articles (05/2014 - 07/2010)|
|10.||Qi, Wei: 3 articles (05/2014 - 07/2010)|
04/01/1998 - "The purpose of this study was to characterize the effects of sodium 4-phenylbutyrate (phenylbutyrate) on the proliferation, morphology, migration and invasiveness of malignant glioma cells in vitro. "
08/18/2007 - "The precursor of AN-113, 4-phenylbutyrate has shown promising results in a Phase I study of gliomas, and we hypothesized that AN-113 offers significant advantages over the parent drug. "
11/23/2007 - "In addition, glycerol and sodium 4-phenylbutyrate reduced the amount of Hsc70 expressed in glioma cells to levels found in normal astrocytes. "
08/18/2007 - "AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines."
11/05/2004 - "We have previously shown that the histone deacetylase inhibitor 4-phenylbutyrate (4-PB) enhances gap junction communication between glioma cells in culture. "
12/15/2014 - "4-Phenylbutyric acid (4-PBA), a chemical chaperone widely used as an ER stress reducer, attenuated Tg-induced myeloid-derived suppressor cell (MDSC) expansion and tumor growth. "
11/01/2004 - "4-Phenylbutyrate (PB) induces differentiation and is being intensively studied as a treatment for brain, prostate, breast, and hematopoietic cancer. "
03/01/2003 - "Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate."
06/01/2012 - "Here, we showed that long exposure to 4-phenylbutyric acid (PBA), a chemical chaperone that can reduce retention of unfolded and misfolded proteins in ER, induced cellular senescence in cancer cells such as MCF7 and HT1080. "
11/01/2004 - "Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate."
|3.||Kidney Diseases (Kidney Disease)
04/11/2014 - "No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease."
07/01/2015 - "In some cases, chemical chaperones, such as 4-phenylbutyrate and taurodeoxycholic acid, relieve the symptoms, indicating that ER stress-induced apoptosis of renal cells is one of the major causes of certain kidney diseases. "
10/01/2005 - "Colchicine and sodium 4-phenylbutyrate reverse these processes and could potentially be beneficial in ameliorating the progressive renal damage in uromodulin-associated kidney diseases."
02/01/2012 - "The aim of this study was to assess the impact of 4-phenylbutyrate (4-PB) and its immunological effects on the macrophage clearance of apoptotic pancreatic ductal adenocarcinoma (PDAC) cells. "
02/01/1988 - "1-Aryl-3-(2-chloroethyl) ureas and 1-aryl-3-nitroso-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanilines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. "
05/08/2014 - "4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum."
05/01/2013 - "Treatment of db/db mouse islets with the chemical chaperone 4-phenylbutyric acid partially restored the changes in several β-cell function genes and transcription factors but did not affect inflammation or antioxidant gene expression. "
12/01/2013 - "In OVA(LPS)-OVA mice 4-phenylbutyric acid (4-PBA), a chemical chaperone, significantly reduced the increases in ER stress, nuclear translocation of nuclear factor κB, inflammatory cytokine levels, dendritic cell infiltration, Toll-like receptor 4 expression, airway inflammation, and bronchial hyperresponsiveness, whereas it further enhanced the increase in IL-10 levels. "
01/01/2013 - "Specifically, HDAC inhibitors such as trichostatin A, valproic acid, sodium butyrate, sodium 4-phenylbutyrate, and suberoylanilide hydroxamic acid have been shown to provide robust protection against excitotoxicity, oxidative stress, ER stress, apoptosis, inflammation, and bloodbrain barrier breakdown. "
|1.||Histone Deacetylase Inhibitors
|6.||Valproic Acid (Valproate, Semisodium)
|7.||progressive familial intrahepatic 1 Cholestasis
|8.||trichostatin A (A 300)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)