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BRL 46470
a 5-HT3 receptor antagonist and anxiolytic compound; BRL 46470A is the hydrochloride salt
Also Known As:
BRL 46470A; BRL-46470; BRL-46470A; endo-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3,3-dimethylindole-1-carboxamide
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Bridged-Ring Heterocyclic Compounds
Heterocyclic Bridged Bicyclo Compounds
BRL 46470: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
BRL 46470: 5
Related Diseases
1.
Panic Disorder (Panic Attack)
09/01/1994 - "
In this double-blind placebo-controlled crossover study in 12 healthy men who were volunteers, infusion of mCPP caused significant increases in self-ratings for the psychological and physical symptoms of anxiety, for the symptoms of panic attack, and in the plasma levels of cortisol and prolactin, with four subjects (33%) experiencing an mCPP-induced "panic attack." Pretreatment with BRL 46470 did not attenuate any of these mCPP-induced changes.
"
2.
Vomiting
06/01/1994 - "
BRL 46470 (0.05-0.5 mg kg-1, p.o.) dose-dependently prevented emesis evoked over a 2 h period by total body X-irradiation.
"
3.
Neuroblastoma
08/01/1993 - "
The effect of a novel 5-HT3 receptor antagonist, BRL 46470, has been studied on two electrophysiological models for 5-HT3 receptors: grease-gap recordings from rat isolated vagus nerve and whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma NG108-15 cells.
"
4.
Glioma (Gliomas)
08/01/1993 - "
The effect of a novel 5-HT3 receptor antagonist, BRL 46470, has been studied on two electrophysiological models for 5-HT3 receptors: grease-gap recordings from rat isolated vagus nerve and whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma NG108-15 cells.
"
5.
Catalepsy
08/20/1999 - "
Prazosin (3 or 5 mg/kg), an alpha1-adrenoceptor antagonist, and endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimet hyl-indole-1-carboxamide HCl (BRL-46470A, 0.05 or 0.5 mg/kg), a 5-HT3 receptor antagonist, did not interfere with L-NOARG-induced catalepsy.
"
Related Drugs and Biologics
1.
5-HT3 Serotonin Receptors (5 HT3 Receptor)
2.
Nitroarginine (NG Nitro L Arginine)
3.
Anti-Anxiety Agents (Anxiolytics)
4.
Adrenergic Receptors (Adrenergic Receptor)
5.
Prolactin
6.
Prazosin (Minipress)
7.
Hydrocortisone (Cortisol)
8.
endo-alpha-sialidase
9.
indole