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endosulfine

an endogenous peptidic ligand for the sulfonylurea receptor from the central nervous system & from insulin-secreting beta cells

Also Known As:

alpha-endosulfine; beta-endosulfine

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - endosulfine: 10
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - endosulfine: 10
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - endosulfine: 10

Experts

1.	Kim, S H: 2 articles (09/2001 - 01/2001)
2.	Lubec, G: 2 articles (09/2001 - 01/2001)
3.	Burgess, Andrew: 1 article (01/2018)
4.	Marzec, Kamila: 1 article (01/2018)
5.	Gerzanich, Volodymyr: 1 article (10/2017)
6.	Ivanova, Svetlana: 1 article (10/2017)
7.	Mehta, Rupal I: 1 article (10/2017)
8.	Simard, J M: 1 article (10/2017)
9.	Stokum, Jesse A: 1 article (10/2017)
10.	Tsymbalyuk, Natalia: 1 article (10/2017)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 01/01/2004 - "Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion." 01/01/2004 - "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians." 12/06/2013 - "Endosulfine alpha (ENSA) is an endogenous ligand of sulfonylurea receptor that was reported to be associated with an ATP-dependent potassium channel that controls insulin release and the onset of type 2 diabetes. "
2.	Alzheimer Disease (Alzheimer's Disease) 09/14/2001 - "Brain alpha-endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker and drug target?" 09/14/2001 - "We examined the protein levels of alpha-endosulfine in frontal cortex and cerebellum from patients with Alzheimer's disease (AD). " 01/01/2001 - "We examined the expression levels of alpha-endosulfine protein in frontal cortex and cerebellum from patients with Down syndrome (DS) showing Alzheimer's disease (AD) pathology using Western blotting. "
3.	Stroke (Strokes) 10/01/2017 - "α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke."
4.	Starvation 12/21/2022 - "In parallel to the induction of autophagy, the Greatwall-Endosulfine switch is activated upon nitrogen starvation to down-regulate protein phosphatase PP2A/B55 activity, which is essential for cell cycle arrest in G1 and implementation of the quiescent program. "
5.	Neoplasms (Cancer) 01/01/2018 - "It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Sulfonylurea Receptors
3.	Protein Phosphatase 2 (Protein Phosphatase 2A)
4.	KATP Channels
5.	Centromere Protein B
6.	Ephrin-B2 (Ephrin B2)
7.	Protein Isoforms (Isoforms)
8.	Brain-Derived Neurotrophic Factor (BDNF)
9.	Insulin-Like Growth Factor Binding Protein 2
10.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)