|1.||Guan, Min-Xin: 37 articles (11/2015 - 11/2002)|
|2.||Zhu, Yi: 16 articles (11/2015 - 06/2005)|
|3.||Li, Ronghua: 14 articles (01/2011 - 01/2004)|
|4.||Qian, Yaping: 14 articles (01/2010 - 12/2004)|
|5.||Zheng, Jing: 13 articles (11/2015 - 01/2010)|
|6.||Han, Dongyi: 13 articles (01/2013 - 01/2004)|
|7.||Yang, Li: 13 articles (01/2011 - 02/2005)|
|8.||Young, Wie-Yen: 12 articles (10/2007 - 01/2004)|
|9.||Dai, Pu: 11 articles (01/2015 - 02/2006)|
|10.||Lu, Jianxin: 11 articles (06/2012 - 08/2006)|
|1.||Hearing Loss (Hearing Impairment)
01/01/2015 - "The purpose of the present study was to elucidate the relationship of 12S rRNA gene polymorphisms and age-related hearing loss. "
12/01/2012 - "[Mitochondrial 12S rRNA variants studies in 456 subjects with hearing loss in seven schools for deaf and mutes in Zhejiang province]."
08/01/2011 - "To study the effect of the mitochondrial 12S rRNA mutations on aminoglycoside-induced and nonsyndromic hearing loss, to carry out the clinical and molecular characterization of five Han Chinese pedigrees with maternally transmitted aminoglycoside-induced and nonsyndromic hearing loss. "
12/01/2010 - "The present study confirmed that the mitochondrial 12S rRNA gene is a hot spot for mutations associated with hearing impairment."
04/23/2010 - "In the present study, we have performed mutational screening of entire 12S rRNA gene in 250 unrelated patients with non-syndromic and aminoglycoside-induced hearing loss. "
|2.||Deafness (Deaf Mutism)
11/01/2014 - "[Function study of non-syndromic deafness associated mitochondrial 12S rRNA A839G mutation]."
12/20/2015 - "In contrast, it was recently reported that signaling induced by 'hypermethylation' of two conserved adenosines of 12S rRNA in the mitoribosome is of key pathophysiological importance in sensorineural deafness. "
01/01/2015 - "All patients underwent mutation screening of three common deafness genes: GJB2, SLC26A4 and the mitochondrial 12S rRNA gene. "
01/01/2015 - "Of the known deafness-associated mutations in the mitochondrial 12S rRNA gene, the incidence of the A1555G mutation was 0.15%, A827G was 4.38%, T1095C was 0.45%, and T1005C was 3.78%. "
01/01/2015 - "The mitochondrial 12S rRNA is a hot spot for deafness-associated mutations in Chinese populations. "
|3.||Sensorineural Hearing Loss
01/01/2014 - "This study aims to investigate the mutation spectrum of GJB2, mitochondrial 12S rRNA, and SLC26A4 genes of Han Chinese, Hui people, and Uyghur ethnicities in sensorineural hearing loss (SNHL) patients in northwest of China. "
06/01/2007 - "Mutations in the 12S rRNA gene were screened in a panel of 315 unrelated Taiwanese families with idiopathic sensorineural hearing loss. "
01/01/2007 - "[Screening of the mitochondrial 12S rRNA (MTRNR1) gene in probands with sensorineural hearing loss]."
01/01/2008 - "To elucidate the relative importance of common deafness genes in Taiwanese and to verify our hypothesis, we conducted a prospective project screening mutations in GJB2, SLC26A4 and mitochondrial 12S rRNA gene in a total of 420 Taiwanese families with idiopathic bilateral sensorineural hearing loss, of which 325 families were recruited from hospitals and 95 from hearing rehabilitation facilities. "
09/01/2010 - "Mutations in mitochondrial DNA (mtDNA), especially the A1555G transition in the 12S rRNA gene, are one of the causes of both aminoglycoside-induced and non-syndromic sensorineural hearing loss. "
01/07/2005 - "To detect the variations of mitochondrial 12S rRNA in patients with gastric carcinoma, and to study their significance and the relationship between these variations and the genesis of gastric carcinoma. "
05/01/2005 - "There existed statistically significant difference in variant frequency of 12S rRNA between intestinal type and diffuse type of gastric carcinoma, 5/17 (29.4%) and 12/17 (70.6%) respectively (P < 0.05). "
05/01/2005 - "[Mutation of mitochondrial 12S rRNA in gastric carcinomas and its significance]."
01/07/2005 - "During the process from normality to dysplasia, then to carcinoma, 12S rRNA tends to convert from homoplasmy (wild type) to heteroplasmy, then to homoplasmy (mutant type, np717 T-G)."
01/07/2005 - "The mutations of mitochondrial 12S rRNA may be associated with the occurrence of intestinal-type gastric carcinoma. "
|5.||Stomach Neoplasms (Stomach Cancer)
05/01/2005 - "Highly variant frequency of mitochondrial 12S rRNA may be associated with intestinal type of gastric cancer. "
05/01/2005 - "To detect the alterations of mitochondrial 12S rRNA in patients with gastric cancer, and further evaluate their effects on development of gastric carcinomas. "
09/01/2003 - "To explore the instabilities, polymorphisms and other variations of mitochondrial D-loop region and downstream gene 12S rRNA-tRNA(phe) in gastric cancers, and to study their relationship with gastric cancer. "
05/01/2005 - "Mitochondrial 12S rRNA of 22 samples of gastric cancer tissues and 22 corresponding normal gastric mucosa taken from the distal portion of surgical specimens were PCR amplified, followed by direct DNA sequencing. "
09/01/2003 - "The poorly differentiated gastric cancers are more prone to 12S rRNA-tRNA(phe) variations, or gastric cancers with 12S rRNA-tRNA(phe) variations are more likely to be poorly differentiated. "
|2.||Mitochondrial DNA (mtDNA)
|3.||Electron Transport Complex IV (Cytochrome c Oxidase)
|4.||Ser Transfer RNA
|5.||Leu Transfer RNA
|6.||Cytochromes b (Cytochrome b)
|7.||RNA (Ribonucleic Acid)
|8.||Lys Transfer RNA
|9.||Arg Transfer RNA
|10.||Phe Transfer RNA
|1.||Stem Cell Transplantation
|3.||Drug Therapy (Chemotherapy)