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tryptase Clara

from rat lung; preferentially recognizes a single arginine cleavage site cleaving Boc-Gln-Ala-Arg-4-methylcoumaryl-7-amide most efficiently; possible activator of inactive viral fusion glycoprotein in the respiratory tract and thus responsible for pneumopathogenicity of the virus
Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kuwajima, Masamichi: 1 article (06/2004)
2. Shiota, Mayumi: 1 article (06/2004)
3. Yao, Dengfu: 1 article (06/2004)
4. Chen, Ye: 1 article (06/2004)
5. Kido, Hiroshi: 1 article (06/2004)

Related Diseases

1. Infection
2. Human Influenza (Influenza)
01/01/1999 - "We report here that human mucus protease inhibitor (MPI), a major inhibitor of granulocyte elastase in the lining fluid of the human respiratory tract, significantly inhibited induction of the infectivity of influenza A and Sendai viruses by tryptase Clara in vitro and multicycles of mouse-adapted influenza A virus replication in rat lungs in vivo. "
01/01/1999 - "Tryptase Clara, a trypsin-like protease localized exclusively in and secreted by Clara cells of the bronchial epithelium, is a prime host factor that processes viral envelope glycoproteins and determines the infectivity of influenza A and Sendai viruses (H. "
02/01/1997 - "We report here that human mucus protease inhibitor (MPI), a major inhibitor of granulocyte elastase in the lining fluids of the human respiratory tract, significantly inhibited proteolytic activation of the infectivity of influenza A and Sendai viruses by tryptase Clara in vitro and multi-cycles of mouse-adapted influenza A virus replication in rat lungs in vitro. "
01/01/1996 - "Here we described the host cellular processing proteases, tryptase Clara and tryptase TL2, which proteolytically activate the infectivity of influenza A and Sendai viruses in the respiratory tract and HIV-1 in human CD4+ T cells, respectively. "
06/01/2004 - "The common epidemic human influenza A virus is pneumotropic and the HA processing proteases tryptase Clara, mini-plasmin, tryptase TC30 and ectopic anionic trypsin have all been isolated from mammalian airways. "

Related Drugs and Biologics

1. Secretory Leukocyte Peptidase Inhibitor
2. Leukocyte Elastase (Neutrophil Elastase)
3. Trypsin
4. Peptide Hydrolases (Proteases)
5. Glycoproteins (Glycoprotein)
6. Tryptases (Tryptase)
7. Pulmonary Surfactants (Pulmonary Surfactant)
8. Phenobarbital (Luminal)
9. Fibrinolysin
10. Antigens