|1.||Pejler, Gunnar: 8 articles (12/2015 - 05/2007)|
|2.||Theocharis, Achilleas D: 5 articles (01/2015 - 11/2006)|
|3.||Abrink, Magnus: 4 articles (01/2015 - 05/2007)|
|4.||Karamanos, Nikos K: 4 articles (01/2015 - 11/2006)|
|5.||Åbrink, Magnus: 3 articles (12/2015 - 12/2010)|
|6.||Korpetinou, Angeliki: 3 articles (01/2015 - 01/2013)|
|7.||Labropoulou, Vassiliki T: 3 articles (01/2015 - 01/2013)|
|8.||Melo, Fabio R: 3 articles (03/2014 - 05/2012)|
|9.||Wernersson, Sara: 3 articles (12/2012 - 12/2010)|
|10.||Grujic, Mirjana: 3 articles (12/2012 - 07/2008)|
01/01/2015 - "Our study investigated for first time the distribution of serglycin in normal epithelial and cancerous lesions in most common cancer types. "
09/01/2012 - "In addition, we review recent studies on the involvement of serglycin in various pathological conditions, including cancer, inflammatory diseases, and platelet disorders."
01/01/2015 - "In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization. "
01/01/2015 - "In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry. "
01/01/2015 - "It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels. "
|2.||Acute Erythroblastic Leukemia (Erythroleukemia)
07/06/2001 - "We have compared regulation of the serglycin gene in human erythroleukemia (HEL) and CHRF 288-11 cells, which have megakaryocytic characteristics, with promyelocytic HL-60 cells. "
07/06/2001 - "Promoter regulatory elements and DNase I-hypersensitive sites involved in serglycin proteoglycan gene expression in human erythroleukemia, CHRF 288-11, and HL-60 cells."
12/01/1993 - "This study has determined the effects of phorbol-12-myristate-13-acetate (PMA) and dimethylsulfoxide (DMSO) on mRNA levels for the serglycin proteoglycan core protein in human erythroleukemia (HEL) cells. "
01/01/1995 - "Human megakaryocytic tumor cell lines CHRF-288-11 and HEL (human erythroleukemia) were incubated with antisense phosphodiester (PDE) and phosphorothioate (PS) oligodeoxynucleotides directed against the first six codons of the human serglycin proteoglycan gene. "
12/01/1993 - "Expression of mRNA for serglycin core protein and other platelet alpha granule proteins is increased in human erythroleukemia cells by phorbol myristate acetate."
09/12/2003 - "Cells derived from a serglycin-processing mouse mastocytoma expressed a protein highly similar to other mammalian heparanases. "
06/01/1993 - "The mouse T lymphocyte cell line EL4.E1 synthesizes a proteoglycan core protein (PGCP) mRNA which is identical to serglycin mRNA found in mouse bone marrow-derived mast cells and a mouse mastocytoma cell line. "
02/07/1997 - "In order to study the subcellular localization and organization of the enzymes involved in the glycosylation of the hybrid proteoglycan serglycin, mouse mastocytoma cells were metabolically labeled with [35S]sulfate or [3H]glucosamine in the absence or presence of brefeldin A. "
07/15/2008 - "In this study, the role of serglycin during viral infection was studied by infecting wild-type (wt) mice and serglycin-deficient (SG(-/-)) mice with lymphocytic choriomeningitis virus (LCMV). "
07/15/2008 - "Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin."
12/03/2010 - "However, serglycin-deficient mice secreted mast cell proteases at wild type levels at the site of infection, and enzymatic activities associated with mast cell proteases were equally up-regulated in wild type and serglycin-deficient mice 48 h after infection. "
12/03/2010 - "To address this issue, we studied the effects on mast cell proteases in serglycin-deficient and wild type mice after peritoneal infection with the obligate intracellular parasite Toxoplasma gondii. "
12/03/2010 - "However, the importance of serglycin for secretion and activity of mast cell proteases in response to parasite infection has been poorly investigated. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2013 - "In the present study, we show for the first time the in situ expression of serglycin by breast cancer cells by immunohistochemistry in patients' material. "
01/01/2013 - "Stable expression of serglycin in less aggressive MCF-7 breast cancer cells induced their proliferation, anchorage-independent growth, migration and invasion. "
01/01/2013 - "Moreover, we demonstrate high expression and constitutive secretion of serglycin in the aggressive MDA-MB-231 breast cancer cell line. "
01/01/2013 - "Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells."
01/01/2015 - "In recent years, expression of serglycin has also been found in different forms of human malignancies and a high serglycin expression level has been correlated with a more migratory and invasive phenotype in the case of breast cancer and nasopharyngeal carcinoma. "
|2.||Messenger RNA (mRNA)
|6.||Dimethyl Sulfoxide (DMSO)
|7.||Peptide Hydrolases (Proteases)
|8.||Complement System Proteins (Complement)
|10.||Hepatocyte Growth Factor (Growth Factor, Hepatocyte)