BW 737C89

structure given in first source; highly potent dopamine D1 receptor antagonist; BW-737C is the (S)-isomer; BW-736C is the (R)-isomer

Also Known As:

6-chloro-1-(2,5-dimethoxy-4-propylbenzyl)-7-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; BW 736C; BW 737C; BW-736C; BW-737C; BW-737C89; BW737C89; 7-Isoquinolinol, 6-chloro-1-((2,5-dimethoxy-4-propylphenyl)methyl)-1,2,3,4-tetrahydro-2-methyl-, (S)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        BW 737C89: 2

Related Diseases

1.	Myoclonus (Nocturnal Myoclonus) 12/19/1996 - "Sniffing and locomotor responses to RU 24213 were attenuated by BW 737C and SCH 23390 but not by LY 270411; furthermore, myoclonic jerking to RU 24213 was released by BW 737C and SCH 23390 but not by LY 270411. "
2.	Catalepsy 08/01/1994 - "The dopamine D1 receptor antagonists SCH 39166 ((-)-trans-6-7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N- methyl-5H-benzo(d)naphtho-(2,1-b)azepine) and BW 737C89 ([S]-6-chloro-1-[2,5-dimethoxy-4-propylbenzyl]-7- hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) produced dose-related increases in the duration of static and unusual postures, indicative of catalepsy. "

Related Drugs and Biologics

1.	Dopamine D1 Receptors (Dopamine D1 Receptor)
2.	SCH 23390
3.	LY 270411
4.	ecopipam
5.	N- n- propyl- N- phenylethyl- 4(3- hydroxyphenyl)ethylamine hydrochloride
6.	1,2,3,4-tetrahydroisoquinoline
7.	S 6 (S-6)