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N-ethoxycarbonyl-7-oxostaurosporine

structure given in first source

Also Known As:

N-ethoxycarbonyl-7-oxo-staurosporine; NA 382; NA-382

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 04/01/1993 - "The effects of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on multidrug resistance in tumor cells were investigated. " 06/01/1995 - "This study indicates that NA-382 is more effective against multidrug-resistance than verapamil, and its suspension is also advantageous for cancer chemotherapy of multidrug-resistant tumours."
2.	Hepatocellular Carcinoma (Hepatoma) 03/01/1997 - "NA-382 inhibited the adhesion of AH66F cells to the M-cell layer and the expression of LFA-1 on the membrane of the hepatoma cells after treatment for more than 24 h. " 03/01/1997 - "To examine the mechanism of inhibition by protein kinase C (PKC) inhibitors of the adhesion of highly malignant hepatoma AH66F cells to the mesentery-derived mesothelial cell (M-cell) layer through leukocyte function-associated antigen-1 (LFA-1)/intercellular adhesion molecule-1, the effects of a PKC inhibitor, NA-382, on the expression of LFA-1 molecules in AH66F cells were examined and compared with those in thymocytes from normal rats. " 01/01/1996 - "The adhesion of AH66F cells, but not other hepatoma cells, to rat mesentery-derived mesothelial cells was inhibited by protein kinase C inhibitors NA-382 and H-7, but not by other protein kinase inhibitors, and the life-span of rats inoculated with AH66F cells was also prolonged by treatment with Na-382. "
3.	Neoplasm Metastasis (Metastasis) 01/01/1996 - "Metastasis of AH66F cells in the chick embryo was clearly decreased by treatment with NA-382. "

Related Drugs and Biologics

1.	Verapamil (Calan)
2.	Suspensions
3.	Protein Kinase C
4.	Protein Kinase Inhibitors
5.	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)
6.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
7.	Lymphocyte Function-Associated Antigen-1 (LFA-1)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)