ambasilide

class III antiarrhythmic agent

Also Known As:

3-(4-aminobenzoyl)-7-benzyl-3,7-diazabicyclo(3.3.1)nonane; LU 47110; LU-47110

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - ambasilide: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ambasilide: 4
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ambasilide: 4

Experts

1.	Hamlin, David M: 1 article (01/2005)
2.	Hamlin, Robert L: 1 article (01/2005)
3.	Kijtawornrat, Anusak: 1 article (01/2005)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 03/01/1995 - "Therefore ambasilide showed an antifibrillatory effect but provided only a partial protection against lethal arrhythmias induced by acute myocardial ischemia and sympathetic activation." 03/01/1995 - "We assessed the effects of ambasilide, 5 mg/kg intravenous (i.v.) bolus plus 5 mg.kg-1.hr-1 i.v. infusion, in 16 anesthetized cats in which ventricular arrhythmias could be induced reproducibly by the combination of acute myocardial ischemia and increased sympathetic activity. " 03/01/1995 - "Effects of the potassium channel blocking agent ambasilide on ventricular arrhythmias induced by acute myocardial ischemia and sympathetic activation."
2.	Tachycardia (Tachyarrhythmias) 08/01/1996 - "Therefore, ambasilide may be useful in treating tachyarrhythmias in normal, as well as in altered [K+e] conditions." 01/01/2005 - "Ambasilide also inhibited isoproterenol-induced tachycardia, suggesting it exerts beta-adrenergic blocking properties. "
3.	Ventricular Tachycardia 03/01/1995 - "Ambasilide prevented nonsustained ventricular tachycardia in 2 (40%) of 5 animals. " 03/01/1995 - "Ventricular fibrillation was observed in 7 animals and never occurred after ambasilide (p < 0.001); however, 4 (57%) of these cats had sustained ventricular tachycardia requiring cardiac massage. "
4.	Ventricular Fibrillation 03/01/1995 - "Ventricular fibrillation was observed in 7 animals and never occurred after ambasilide (p < 0.001); however, 4 (57%) of these cats had sustained ventricular tachycardia requiring cardiac massage. "
5.	Pericarditis 10/01/1994 - "In an additional 6 dogs with sterile pericarditis and inducible AF, ambasilide prevented AF induction in all 6. An equal dose of d-sotalol (2 mg/kg) failed to suppress AF induction in any dog, but 8 mg/kg of d-sotalol suppressed AF induction in all. "

Related Drugs and Biologics

1.	Adrenergic Agents (Adrenergic Drugs)
2.	Potassium Channels (Potassium Channel)
3.	Sotalol (Sotalol Hydrochloride)
4.	Isoproterenol (Isoprenaline)

Related Therapies and Procedures

1.	Heart Massage