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SC 51316
structure given in first source; an angiotensin II receptor antagonist
Also Known As:
2,5-dibutyl-2,4-dihydro-4-((2-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4'-yl)methyl)-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 2,5-dibutyl-2,4-dihydro-4-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-; SC-51316
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Triazoles: 1533
SC 51316: 4
Tetrazoles: 14
SC 51316: 4
Related Diseases
1.
Atherosclerosis
04/01/1993 - "
To investigate the mechanism by which angiotensin-converting enzyme (ACE) inhibition attenuates atherogenesis, we have studied the effects of a non-sulfhydryl ACE inhibitor, enalapril, and an angiotensin receptor antagonist, SC-51316, in cholesterol-fed rabbits.
"
2.
Ganglion Cysts (Ganglion)
07/01/1993 - "
In anesthetized, ganglion-blocked rats, intravenous administration of SC-51316 inhibited the pressor response to an infusion of AII.
"
3.
Ureteral Obstruction
01/01/1998 - "
Thus changes in VCAM-1 levels may account for the differential effect of enalapril and SC-51316 on monocyte/macrophage infiltration of the kidney during ureteral obstruction.
"
01/01/1998 - "
Rats with unilateral ureteral obstruction (UUO) of 1, 3, or 5 days duration were untreated or given enalapril or SC-51316 in the drinking water.
"
4.
Cardiovascular Diseases (Cardiovascular Disease)
06/01/1992 - "
These data demonstrate that SC-51316 is a potent AII receptor antagonist which may prove to be useful as a pharmacologic tool for studying the role of the renin-angiotensin system in cardiovascular diseases.
"
Related Drugs and Biologics
1.
Enalapril
2.
Drinking Water
3.
Angiotensin Receptor Antagonists
4.
Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
5.
Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.
Cholesterol
7.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
Related Therapies and Procedures
1.
Intravenous Administration