|1.||Fujiwara, Sakuhei: 1 article (06/2014)|
|2.||Zhang, Wei: 1 article (06/2014)|
|3.||Hatano, Yutaka: 1 article (06/2014)|
|4.||Sakai, Takashi: 1 article (06/2014)|
|5.||Segal, P: 1 article (12/2013)|
|6.||Bonneterre, V: 1 article (12/2013)|
|7.||de Gaudemaris, R: 1 article (12/2013)|
|8.||Balducci, F: 1 article (12/2013)|
|9.||Pérennou, D: 1 article (12/2013)|
|10.||Mignot, N: 1 article (12/2013)|
02/01/2013 - "Knockdown of the expression of CH-SPase in WSSV-infected Chinese shrimp reduced the copy number of WSSV and delayed cumulative mortalities, suggesting that CH-SPase is important for WSSV infection. "
11/01/2009 - "Furthermore, we demonstrated that SPase I not only is an attractive target for development of novel antibacterials against free-living bacteria, but also is a feasible target for biofilm-associated infections."
09/01/2012 - "SPase activity is also of fundamental importance to the pathogenesis of infection for many bacteria, including Pseudomonas aeruginosa, which utilizes a variety of secreted virulence factors, such as proteases and toxins. "
|3.||Retinoblastoma (Glioblastoma, Retinal)
04/10/1997 - "Transcription factor, SP1, and retinoblastoma susceptible gene product, RB, are substrates of SPase while other nuclear factors such as c-Jun and c-Fos are not. "
04/01/2005 - "SPase is a cysteine protease isolated from an African green monkey kidney cell line, CV-1, and has selective cleavage activity toward transcription factor SP-1 and retinoblastoma susceptibility gene product RB. "
|4.||Liver Cirrhosis (Hepatic Cirrhosis)
04/01/2002 - "With SPASE, they were 16.4% higher in the acute hepatitis group, 33.3% higher in the chronic hepatitis group, and the positive rates were 73.6% and 61.2% respectively in sera of hepatic cirrhosis patients, which were remarkably higher than those in chronic hepatitis and acute hepatitis group (P<0.001). "
07/10/2001 - "TIMP-1 and TIMP-2 in the serum of 106 patients with liver cirrhosis were detected by solid-phase absorption to sensitized erythrocytes (SPASE). "
04/01/2002 - "SPASE is a useful method to detect the TIMP-1 and TIMP-2 in sera of patients with hepatic cirrhosis, and TIMP-1 and TIMP-2 can be considered as a useful diagnostic index of hepatic fibrosis, especially TIMP-1."
04/01/2002 - "The monoclonal antibodies (McAbs) of TIMP-1 and TIMP-2 were used to sensitize erythrocytes, and solid-phase absorption to sensitized erythrocytes (SPASE) was used to detect TIMP-1 and TIMP-2 in the sera of patients with hepatic cirrhosis. "
|5.||Type A Niemann-Pick Disease
05/01/1978 - "By employing this technique, it was shown that cells from patients with Niemann-Pick disease type A have less than 10% of the normal SPase activity, whereas the heterozygote carriers of this disease have about 50% of the normal activity."
05/01/1978 - "A method is developed for the detection of homozygotes and heterozygote carriers of Niemann-Pick disease type A by employing a high performance liquid chromatography (HPLC) technique for the measurement of sphingomyelin (SP) as well as for the assay of the enzyme sphingomyelinase (SPase) in skin fibroblasts and amniotic fluid cell cultures. "
|1.||Tissue Inhibitor of Metalloproteinase-2
|2.||Tissue Inhibitor of Metalloproteinase-1
|3.||type I signal peptidase (signal peptidase)
|4.||Serine Proteases (Serine Protease)
|5.||Cysteine Proteases (Cysteine Protease)
|7.||Virulence Factors (Pathogenicity Factors)
|8.||Sp1 Transcription Factor
|9.||Transcription Factors (Transcription Factor)
|10.||Sphingomyelin Phosphodiesterase (Sphingomyelinase)