rilmakalim

potassium channel opener; rimalkalim may be a typo

Also Known As:

3-hydroxy-2,3-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-phenylsulfonylchroman hemihydrate; HOE 234; HOE-234; rimalkalim; 2-Pyrrolidinone, 1-(3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)-2H-1-benzopyran-4-yl)-, (3S-trans)-

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromans: 3
        rilmakalim: 4
  - Pyrrolidines: 115
    - rilmakalim: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromans: 3
        rilmakalim: 4

Experts

1.	Kocic, I: 1 article (03/2009)
2.	Sztormowska, K: 1 article (03/2009)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/07/1992 - "Administration of 30 micrograms/kg i.v. HOE 234 during continuous bronchoconstriction maintained by infusion of histamine decreased RL for more than 20 min whereas the effect of 100 micrograms/kg i.v. lemakalin disappeared within 4 min. These results show that HOE 234 is effective against contractile response induced by asthma mediators in guinea pig airways and compares favourably with lemakalim. " 06/01/1996 - "The possible advantages of HOE 234 as an anti-asthma drug might be related to an effect on bronchial hyper-reactivity and mucus secretion, because as a direct bronchodilator it is inferior to salbutamol."
2.	Pulmonary Hypertension 03/01/2009 - "Our results imply that pulmonary hypertension increased sensitivity of sinoatrial cells to isoprenaline and decreased efficacy of rilmakalim to reduce heart rate more significantly in females then in males."
3.	Heart Failure 08/01/1995 - "The functional role of ATP-dependent potassium (KATP) in hypoxic cardiac failure was investigated in isolated guinea pig hearts with glibenclamide and rimalkalim as inhibitor and activator, respectively. "

Related Drugs and Biologics

1.	Cromakalim (Levcromakalim)
2.	Isoproterenol (Isoprenaline)
3.	Histamine (Histamine Dihydrochloride)
4.	Potassium
5.	Glyburide (Glibenclamide)
6.	Bronchodilator Agents (Bronchodilators)
7.	Albuterol (Salbutamol)
8.	Adenosine Triphosphate (ATP)