bryonolic acid

structure given in first source; an anti-allergy agent isolated from Luffa cylindrica, the roots of Bryonia dioica, and the fruit hulls of Sandrica indicum

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Khallouki, Farid: 1 article (02/2018)
2.	Owen, Robert Wyn: 1 article (02/2018)
3.	Poirot, Marc: 1 article (02/2018)
4.	Silvente-Poirot, Sandrine: 1 article (02/2018)
5.	Frahm, August Wilhelm: 1 article (06/2009)
6.	Jiratchariyakul, Weena: 1 article (06/2009)
7.	Kongtun, Sumonthip: 1 article (06/2009)
8.	Kummalue, Tanawan: 1 article (06/2009)
9.	Kunnachak, Somyos: 1 article (06/2009)
10.	Tan-ariya, Peerapan: 1 article (06/2009)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2009 - "Bryonolic acid (1) inhibited MDA-MB435 somewhat better than the other tested human cancer cell lines. " 05/01/1995 - "Bryonolic acid exhibited cytotoxic activity to various tumor cells in vitro, independent of cell type. " 06/01/2009 - "Cucurbitacin (3) inhibited human cancer cell lines, especially Caco-2, much more strongly than bryonolic acid (1). " 02/12/2018 - "Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation."
2.	Melanoma (Melanoma, Malignant) 03/01/1994 - "Bryonolic acid showed strong inhibition of the growth of B-16 melanoma cells."
3.	Lung Neoplasms (Lung Cancer) 06/01/2009 - "The root extract had higher IC (50) values than bryonolic acid (1) against three breast cancer cell lines (MCF7 = 267/121, T47D = 316/124, MDA-MB435 = 140/90 microL/mL) and one lung cancer cell line (A549 = 106/100 microL/mL). " 06/01/2009 - "and bryonolic acid (1), its main constituent, as well as the fruit juice and cucurbitacin B (3), its main constituent, were tested for cytotoxicity against four human breast cancer cell lines (SKBR3, MCF7, T47D, and MDA-MB435), two lung cancer cell lines (A549 and SK-LU1), and one colon cancer cell line (Caco-2). "
4.	Hypersensitivity (Allergy) 02/01/1993 - "Pharmacological tests using mice demonstrated that bryonolic acid or its derivative is active against at least three types of allergies and that its activity could be increased significantly by preparing synthetic derivatives, in particular a potassium salt of its succinate ester. "
5.	Colonic Neoplasms (Colon Cancer) 06/01/2009 - "and bryonolic acid (1), its main constituent, as well as the fruit juice and cucurbitacin B (3), its main constituent, were tested for cytotoxicity against four human breast cancer cell lines (SKBR3, MCF7, T47D, and MDA-MB435), two lung cancer cell lines (A549 and SK-LU1), and one colon cancer cell line (Caco-2). "

Related Drugs and Biologics

1.	Cucurbitacins
2.	Succinic Acid (Succinate)
3.	Salts
4.	Potassium
5.	Fatty Acids (Saturated Fatty Acids)
6.	Esters
7.	Cholesterol Esters (Cholesteryl Esters)
8.	cucurbitacin B