OPC 14117

has both brain function activating effect & protective effect against cerebral ischemia; structure given in first source

Also Known As:

7-hydroxy-1-(4-(3-methoxyphenyl)-1-piperazinyl)acetylamino-2,2,4,6-tetramethylindan; OPC-14117; 1-Piperazineacetamide, N-(2,3-dihydro-7-hydroxy-2,2,4,6-tetramethyl-1H-inden-1-yl)-4-(3-methoxyphenyl)-

Networked: 10 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aoyama, Naoki: 1 article (05/2002)
2.	Katayama, Yoichi: 1 article (05/2002)
3.	Kawamata, Tatsuro: 1 article (05/2002)
4.	Kikuchi, Tetsuro: 1 article (05/2002)
5.	Maeda, Takeshi: 1 article (05/2002)
6.	Mori, Tatsuro: 1 article (05/2002)
7.	Uwahodo, Yasuhumi: 1 article (05/2002)
8.	Yamamoto, Takamitsu: 1 article (05/2002)

Related Diseases

1.	Brain Contusion 05/03/2002 - "Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat." 05/03/2002 - "In the present study, we examined the effects of OPC-14117, a superoxide radical scavenger, on the secondary cellular damage and cognitive dysfunction occurring in a rat model of cerebral contusion induced by a controlled cortical impact (CCI). " 01/01/1997 - "In the present study, behavioral changes and edema formation in rat cortical contusion model were investigated, and the effects of a superoxide radical scavenger, OPC-14117, were tested. " 01/01/1998 - "Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats." 01/01/1997 - "Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats."
2.	Cognitive Dysfunction 07/01/1997 - "Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. " 05/03/2002 - "In the present study, we examined the effects of OPC-14117, a superoxide radical scavenger, on the secondary cellular damage and cognitive dysfunction occurring in a rat model of cerebral contusion induced by a controlled cortical impact (CCI). "
3.	Wounds and Injuries (Trauma) 01/01/1998 - "These changes were significantly attenuated by OPC-14117, which was administered as a single dose immediately following trauma induction. " 05/01/1992 - "These results demonstrate that OPC-14117 inhibits H2O2 generation by stimulated human leukocytes and support further studies of its effects in disorders such as CNS focal ischemia and trauma, conditions where antioxidant therapy may be beneficial."
4.	Edema (Dropsy) 01/01/1997 - "In the present study, behavioral changes and edema formation in rat cortical contusion model were investigated, and the effects of a superoxide radical scavenger, OPC-14117, were tested. " 01/01/1998 - "Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats." 01/01/1997 - "Antioxidant, OPC-14117, attenuates edema formation and behavioral deficits following cortical contusion in rats." 01/01/1997 - "These findings suggest that superoxide free radicals are involved in contusion-induced edema formation, necrosis formation, and behavioral deficits, and that OPC-14117 has a therapeutic potential to prevent secondary cell damage following traumatic brain injury."
5.	HIV Infections (HIV Infection) 07/01/1997 - "These results demonstrate that this antioxidant intervention is well tolerated in cognitively impaired patients with advanced HIV infection, and suggest that a larger efficacy trial to assess the impact of OPC-14117 on cognitive performance is warranted."

Related Drugs and Biologics

1.	Antioxidants
2.	Superoxides (Superoxide)
3.	Vitamin E
4.	Free Radical Scavengers
5.	Free Radicals

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration