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3,4,5-trihydroxybenzamidoxime

structure given in first source
Also Known As:
VF 233; VF-233; trimidox
Networked: 18 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Elford, Howard L: 5 articles (02/2006 - 08/2002)
2. Mayhew, Christopher N: 3 articles (01/2005 - 11/2002)
3. Gallicchio, Vincent S: 3 articles (01/2005 - 11/2002)
4. Elford, H L: 3 articles (11/2000 - 04/2000)
5. Osanai, Yuu: 2 articles (03/2008 - 05/2007)
6. Ishikawa, Masaaki: 2 articles (03/2008 - 05/2007)
7. Kurauchi, Kaori: 2 articles (03/2008 - 05/2007)
8. Ohtake, Takaharu: 2 articles (03/2008 - 05/2007)
9. Kanno, Syu-Ichi: 2 articles (03/2008 - 05/2007)
10. Ujibe, Mayuko: 2 articles (03/2008 - 05/2007)

Related Diseases

1. Pancreatic Neoplasms (Pancreatic Cancer)
2. Leukemia
3. Reperfusion Injury
4. Ischemia
5. Murine Acquired Immunodeficiency Syndrome (MAIDS)
11/01/2002 - "We report a comparison of the efficacy and bone marrow toxicity of HU (400 and 200 mg/kg/day) with the novel RR inhibitors and free radical-scavenging compounds didox (DX; 3,4-dihydroxybenzohydroxamic acid; 350 mg/kg/day) and trimidox (TX; 3,4,5-trihydroxybenzamidoxime; 175 mg/kg/day) in the murine AIDS (LPBM5 MuLV) model of retrovirus infection. "
01/01/2005 - "In this report we have compared the antiviral effects of HU and two novel RR inhibitors trimidox (3,4,5-trihydroxybenzamidoxime) and didox (3,4-dihydroxybenzohydroxamic acid) in combination with didanosine (2,3-didoxyinosine; ddI) in the LPBM5 MuLV retrovirus model (murine AIDS). "
11/01/1997 - "We examined a new series of RRIs, 3,4-dihydroxybenzohydroxamic acid (Didox) and 3,4,5-trihydroxybenzohydroxamidoxime (Trimidox) for their ability to alter disease progression in murine acquired immunodeficiency syndrome (MAIDS), both alone and in combination with 2',3'-dideoxyinosine (ddI). "
11/01/2002 - "Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea."
06/01/2004 - "In this study, the novel RR inhibitors didox (DX; 3,4-dihydroxybenzohydroxamic acid), and trimidox (TX; 3,4,5-trihydroxybenzamidoxime) were evaluated along with HU for anti-retroviral efficacy in LPBM5-induced retro-viral disease (MAIDS) both as monotherapeutic regimens and in combination with the guanine containing NRTI abacavir (ABC). "

Related Drugs and Biologics

1. Ribonucleotide Reductases (Ribonucleotide Reductase)
2. Hydroxyurea (Hydrea)
3. Hydroxyl Radical
4. tiazofurin
5. 3,4-dihydroxybenzohydroxamic acid
6. Hemoglobins (Hemoglobin)
7. Guanine
8. abacavir (Ziagen)
9. gemcitabine
10. Didanosine (Videx)

Related Therapies and Procedures

1. Radiotherapy
2. Drug Therapy (Chemotherapy)